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      Human Valvular Disease in Coxsackie B 4 Virus Infection

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      Cardiology

      S. Karger AG

      Viral valvulitis, Rheumatic heart disease, Coxsackie virus

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          Abstract

          Valvular tissue from a patient with possible Coxsackie B<sub>4</sub> virus infection was studied. Antigen to Coxsackie B<sub>4</sub> virus was detected in cells of the mitral valve by immunofluorescent staining. Histologic examination of the mitral valve revealed widespread increase in collagenous fibers, subendocardial edema and infiltration of basophilic cells, formation of verruca on the mitral valve surface, and fibrinoid degeneration of collagen fibers. Fragmented fibroblasts and numerous fibers of elastin were observed electron microscopically. The pathologic changes were similar to lesions of endocarditis in rheumatic fever. This case reveals the possible role of viruses in production of valvular heart disease in man usually attributed to rheumatic fever due to streptococcal infections.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1974
          1974
          29 October 2008
          : 59
          : 2
          : 83-91
          Affiliations
          Department of Medicine, School of Medicine, Tulane University, and Charity Hospital of Louisiana, New Orleans, La.
          Article
          169667 Cardiology 1974;59:83–91
          10.1159/000169667
          4434362
          © 1974 S. Karger AG, Basel

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          Pages: 9
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