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      Molecular evidence to support the expansion of the hostrange of Chlamydophila pneumoniae to include reptiles as well as humans, horses, koalas and amphibians.

      Systematic and applied microbiology

      Species Specificity, Amphibians, Sequence Analysis, DNA, Sensitivity and Specificity, microbiology, classification, Reptiles, analysis, RNA, Ribosomal, 16S, RNA, Bacterial, methods, Polymerase Chain Reaction, Molecular Sequence Data, Marsupialia, Immunohistochemistry, Humans, Horses, Disease Reservoirs, isolation & purification, genetics, Chlamydophila pneumoniae, diagnosis, Chlamydophila Infections, chemistry, Bacterial Outer Membrane Proteins, Animals

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          Abstract

          The Chlamydiales are a family of unique intracellular pathogens that cause significant disease in humans, birds and a wide range of animal hosts. Of the currently recognized species, Chlamydophila (previously Chlamydia) pneumoniae, unlike the other chlamydial species, has been previously considered to be solely a pathogen of humans, causing significant respiratory disease and has also been strongly connected with cardiovascular disease. Here we report the finding that strains of C. pneumoniae are widespread in the environment, being detected by molecular methods in a range of reptiles (snakes, iguanas, chameleons) and amphibians (frogs, turtles). Of particular interest was the finding that genotyping of the chlamydial major outer membrane protein gene in these newly identified C. pneumoniae strains showed that many were genetically very similar, if not identical to the human respiratory strains. Whether these reptilian and amphibian strains of C. pneumoniae are still capable of infecting humans, or crossed the host barrier some time ago, remains to be determined but may provide further insights into the relationship of this common respiratory infection with its human host.

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          Author and article information

          Journal
          10.1078/0723-2020-00086
          12086181

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