Blog
About

35
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Hypoxia-inducible factors and the response to hypoxic stress.

      Molecular Cell

      physiology, Animals, Anoxia, physiopathology, Basic Helix-Loop-Helix Transcription Factors, metabolism, Cell Hypoxia, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Models, Biological, Neoplastic Stem Cells, Signal Transduction, Stress, Physiological

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Oxygen (O(2)) is an essential nutrient that serves as a key substrate in cellular metabolism and bioenergetics. In a variety of physiological and pathological states, organisms encounter insufficient O(2) availability, or hypoxia. In order to cope with this stress, evolutionarily conserved responses are engaged. In mammals, the primary transcriptional response to hypoxic stress is mediated by the hypoxia-inducible factors (HIFs). While canonically regulated by prolyl hydroxylase domain-containing enzymes (PHDs), the HIFα subunits are intricately responsive to numerous other factors, including factor-inhibiting HIF1α (FIH1), sirtuins, and metabolites. These transcription factors function in normal tissue homeostasis and impinge on critical aspects of disease progression and recovery. Insights from basic HIF biology are being translated into pharmaceuticals targeting the HIF pathway. Copyright © 2010 Elsevier Inc. All rights reserved.

          Related collections

          Author and article information

          Journal
          20965423
          3143508
          10.1016/j.molcel.2010.09.022

          Comments

          Comment on this article