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      Mechanism of Potassium Relaxation of Arterial Muscle

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          Abstract

          Strips of arterial muscle were prepared from rat tail and femoral arteries and dog mesenteric arteries. All muscles developed a contracture slowly when exposed to a potassium-free solution, but relaxed rapidly when potassium was added to the bath to give a concentration as low as 0.1 mM. The slow contracture is caused by norepinephrine release from intrinsic nerve endings, but the rapid relaxation occurs while the norepinephrine concentration is still high. Contractions produced by exogenous norepinephrine or serotonin in a potassium-free bath were also made to relax by the addition of potassium. After several minutes these relaxations reversed abruptly and spontaneously to return to their original level of contraction. The rapid relaxation was found to be due to an electrogenic transport mechanism which caused hyperpolarization within several seconds after the addition of potassium. This hyperpolarization is believed to be caused by electrogenic ion transport since it exceeded the expected membrane potential based on the potential calculated from potassium concentrations, ER. Hyperpolarization declined within 5–15 min, allowing contraction to redevelop. Ouabain was found to prevent both the 1 Supported by USPHS NIH grants HL-03756, HL-14388, HL-16328, and NS-10558. 2 Recipient of Research Career Development award HL-00073 from the National Institutes of Health.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1977
          1977
          18 September 2008
          : 14
          : 5
          : 261-276
          Affiliations
          Departments of Physiology and Pharmacology, University of Michigan, Ann Arbor, Mich., and Department of Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa
          Article
          158133 Blood Vessels 1977;14:261–276
          10.1159/000158133
          © 1977 S. Karger AG, Basel

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          Pages: 16
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