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      Strong Association of Idiopathic Membranous Nephropathy with HLA-DR2 and MTl in Japanese

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          Abstract

          HLA-A, B, DR, and MT antigens were examined in 50 patients with idiopathic membranous nephropathy (IMN) by the standard microlymphocytotoxicity technique. The frequency of HLA-DR2 was significantly increased in the patients in comparison to the controls. Significant decreases in the frequencies were seen for HLA-DR4, DRw8 and DRw9 in the patients. The linkage disequilibrium between HLA-Bw52 and DR2 was noted in the controls, but it was significantly weaker in the patients. The frequency of MTl was significantly higher, and that of MT3 was significantly lower in the patients as compared with the controls. The findings suggest that an immunological disturbance under the influence of genetic factors may confer a susceptibility to IMN.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1984
          1984
          03 December 2008
          : 36
          : 4
          : 242-245
          Affiliations
          Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo; Department of Surgery and Medicine, National Sakura Hospital, Sakura; Department of Medicine, Chiba Shakaihoken Hospital, Chiba; Research Institute, National Cardio-Vascular Center, Osaka; Department of Transplantation, Tokai University School of Medicine, Isehara, Japan
          Article
          183162 Nephron 1984;36:242–245
          10.1159/000183162
          6424039
          2e2715eb-490e-41ee-859a-983ad4b062b7
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 06 June 1983
          Page count
          Pages: 4
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          Immune suppression genes,HLA-DR antigens,Linkage disequilibrium,MT antigens,Immune response genes,Idiopathic membranous nephropathy

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