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      Strong Association of Idiopathic Membranous Nephropathy with HLA-DR2 and MTl in Japanese

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          Abstract

          HLA-A, B, DR, and MT antigens were examined in 50 patients with idiopathic membranous nephropathy (IMN) by the standard microlymphocytotoxicity technique. The frequency of HLA-DR2 was significantly increased in the patients in comparison to the controls. Significant decreases in the frequencies were seen for HLA-DR4, DRw8 and DRw9 in the patients. The linkage disequilibrium between HLA-Bw52 and DR2 was noted in the controls, but it was significantly weaker in the patients. The frequency of MTl was significantly higher, and that of MT3 was significantly lower in the patients as compared with the controls. The findings suggest that an immunological disturbance under the influence of genetic factors may confer a susceptibility to IMN.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1984
          1984
          03 December 2008
          : 36
          : 4
          : 242-245
          Affiliations
          Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo; Department of Surgery and Medicine, National Sakura Hospital, Sakura; Department of Medicine, Chiba Shakaihoken Hospital, Chiba; Research Institute, National Cardio-Vascular Center, Osaka; Department of Transplantation, Tokai University School of Medicine, Isehara, Japan
          Article
          183162 Nephron 1984;36:242–245
          10.1159/000183162
          6424039
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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