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Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.
Andri Rauch
1 ,
Zoltán Kutalik ,
Patrick Descombes ,
Tao Cai ,
Julia Di Iulio ,
Tobias Mueller ,
Murielle Bochud ,
Manuel Battegay ,
Enos Bernasconi ,
Jan Borovicka ,
Sara Colombo ,
Andreas Cerny ,
Jean-François Dufour ,
Hansjakob Furrer ,
Huldrych F Günthard ,
Markus Heim ,
Bernard Hirschel ,
Raffaele Malinverni ,
Darius Moradpour ,
Beat Müllhaupt ,
Andrea Witteck ,
Jacques S Beckmann ,
Thomas Berg ,
Sven Bergmann ,
Francesco Negro ,
Amalio Telenti ,
Pierre-Yves Bochud
Apr 2010
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Abstract
Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of infected persons; approximately 50% of these do not respond to therapy. We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy.