Cardiac contractility modulation signals improve exercise intolerance and maladaptive regulation of cardiac key proteins for systolic and diastolic function in HFpEF.

[1 ] Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany. Electronic address: carsten.tschoepe@charite.de.

[2 ] Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany.

[3 ] Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany.

[4 ] Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany.

[5 ] Charité-University-Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, German.

[6 ] Heart and Vascular Center (HGZ), Bad Bevensen, Germany.

[7 ] Medical College of Wisconsin, Milwaukee, USA.

[8 ] Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, Germany.

[9 ] Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany; Department of Cardiology, Deutsches Herzzentrum Berlin (DHZB), Berlin, Germany.