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      A cholic acid-based fluorescent chemosenor for the detection of ATP

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      Org. Biomol. Chem.
      Royal Society of Chemistry (RSC)

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          Abstract

          A novel ditopic cholic acid-based fluorescent chemosensor for ATP, 1a, was designed and synthesized. Its interactions with phosphates, AMP, ADP, ATP, CTP, GTP, and TTP have been investigated. When ATP was added to a 1:1 aqueous CH3CN solution of the sensor at pH 7.4, a significant decrease in fluorescence of 1a was observed, whereas other guest molecules showed a much smaller effect. The complex between 1a and ATP was confirmed through combined UV, 1H, 13C and 31P NMR spectroscopic methods. The uniqueness of the new sensor is that it binds with ATP 33-124 times more selectively than other nucleotides, as evidenced from the respective binding constants. 1a is a highly sensitive sensing probe; as little as 30 nM ATP can cause 15% fluorescence quenching of the sensor.

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                Author and article information

                Journal
                OBCRAK
                Org. Biomol. Chem.
                Org. Biomol. Chem.
                Royal Society of Chemistry (RSC)
                1477-0520
                1477-0539
                2008
                2008
                : 6
                : 1
                : 162-168
                Article
                10.1039/B715086E
                18075662
                2e350039-92b1-40cf-83f5-3f13d1f66ffe
                © 2008
                History

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