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      Logistic regression analysis of risk factors of 158 MDR-TB patients in Sanya, Hainan

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          Abstract

          Objective To investigate the risk factors of 158 patients with multi-drug resistant tuberculosis (MDR-TB) in Sanya, and we provide scientific basis for the prevention and treatment of MDR-TB.

          Methods The correlation between 158 MDR-TB patients (case group) and 316 sensitive TB patients (control group) in Sanya was investigated by single-factor and multivariate logistic regression. Univariate and multivariate Logistic regression were used to analyze the risk factors of MDR- TB.

          Results Univariate and multivariate Logistic regression analysis showed that residence ( OR=2.308, 95% CI: 1.597­5.104), previous anti-tuberculosis treatment history ( OR=16.218,95% CI: 14.815-25.106), tuberculosis cavity ( OR=2.904, 95% CI: 2.116-7.915), discontinuation of treatment ( OR=5.706, 95% CI: 4.508-12.319), adverse reactions to antituberculosis drugs ( OR=3.382, 95% CI: 2.672-10.137), irregular drug use ( OR=2.508’ 95% CI: 1.813-5.646) and first antituberculosis therapeutic effect ( OR=3.513, 95%CI: 2.914-10.870) were risk factors for MDR-TB.

          Conclusion There are many risk factors for the occurrence of MDR-TB in Sanya, and early detection, standardized diagnosis and treatment need to be further strengthened to reduce the occurrence of MDR-TB.

          Abstract

          摘要:目的 探讨 亚市158例耐多药结核病(MDR-TB)患者的危险因素,为MDR-TB的防治提供科学依据。 方法 亚市158例MDR-TB患者(病例组)和316例敏感性结核患者(对照组)的相关情况进行调查,应用单因素及 多因素Logistic回归模型分析MDR-TB发生的危险因素。 结果 单因素及多因素Logistic回归分析显示,居住地(O权= 2.308,95%CI: 1.597~5.104)、既往抗结核治疗史(O权=16.218,95%a: 14.815~25.106)、结核空洞(O权=2.904,95%a: 2.116~7.915)、治疗过程中断(0权=5.706,95%67:4.508~12.319)、抗结核药物不良反应(0权=3.382,95%67:2.672~ 10.137)、不规律用药(O权=2.508,95%a: 1.813~5.646)及首次抗结核治疗效果(O权=3.513,95%a: 2.914~10.870)是 MDR-TB发生的危险因素。 结论三 亚市MDR-TB发生的危险因素较多,需要进一步加强早期发现和规范诊疗,以减 少MDR-TB的发生。

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          Journal
          CTM
          China Tropical Medicine
          China Tropical Medicine (China )
          1009-9727
          01 August 2020
          01 August 2020
          : 20
          : 8
          : 789-793
          Affiliations
          1Sanya Central Hospital (The Third People's Hospital of Hainan Province), Sanya, Hainan 572000, China
          Author notes
          Corresponding author: HUANG Lijiu, E-mail: 965133314@ 123456qq.com
          Article
          j.cnki.46-1064/r.2020.08.22
          10.13604/j.cnki.46-1064/r.2020.08.22
          © 2020 Editorial Department of China Tropical Medicine

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

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