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      The safety of a drospirenone-containing oral contraceptive: final results from the European Active Surveillance Study on oral contraceptives based on 142,475 women-years of observation.

      Contraception
      Adult, Androstenes, adverse effects, Arrhythmias, Cardiac, etiology, Contraceptives, Oral, Combined, Female, Humans, Mineralocorticoid Receptor Antagonists, Mortality, Thromboembolism

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          Abstract

          The study was conducted to compare risks of adverse cardiovascular and other events associated with the use of drospirenone (DRSP)-containing oral contraceptives (OCs) and other OCs. The European Active Surveillance study (EURAS) was a multinational, prospective, noninterventional cohort study of new users of DRSP, levonorgestrel (LNG) and other progestin-containing OCs. Semiannual follow-up was based on mailed questionnaires, with additional follow-up procedures when needed. Overall, 58,674 women were followed for 142,475 women-years of observation. Loss to follow-up was 2.4%. Serious adverse and fatal events were rare, and rate ratios were close to unity (1.0). Cox regression analysis of cardiovascular outcomes yielded hazard ratios for DRSP-containing vs. LNG-containing and other OCs of 1.0 and 0.8 (upper 95% confidence limits, 1.8 and 1.3) for venous, and 0.3 and 0.3 (upper 95% confidence limits, 1.2 and 1.5) for arterial thromboembolism, respectively. Risks of adverse cardiovascular and other serious events in users of a DRSP-containing OC are similar to those associated with the use of other OCs.

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          Journal
          17434015
          10.1016/j.contraception.2006.12.019

          Chemistry
          Adult,Androstenes,adverse effects,Arrhythmias, Cardiac,etiology,Contraceptives, Oral, Combined,Female,Humans,Mineralocorticoid Receptor Antagonists,Mortality,Thromboembolism

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