This qualitative study explored stressors experienced by individuals with chronic kidney disease (CKD). Individuals on hemodialysis were asked to share their recollections regarding stressors they experienced as they approached dialysis. Content analysis was used and the following themes emerged: (a) stressors; (b) emotional responses; (c) learning, preparation, and acceptance; and (d) regret and dissatisfaction. The results of this study have important implications for patient education and support in the care of patients with CKD.