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      Effect of Mizoribine on Glomerulonephritis of Early-Stage IgA Nephropathy in ddY Mice

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          Immunopathological studies were performed to determine whether the glomerular injuries in ddY mice, a model for IgA nephropathy (Berger’s disease), are influenced by treatment with mizoribine, a new immunosuppressive agent. The ddY mice were treated with a low (0.05 mg/ml) or a high (0.1 mg/ml) dose of mizoribine for 35 weeks. Flow cytometry analysis showed that there was a marked decrease in the number of B cells and IgA-bearing B cells. In immunofluorescence, the deposition of IgA in the glomerular mesangial areas and capillary walls of the high-dose mizoribine-treated ddY mice was markedly decreased as compared with that of control ddY mice receiving drinking water. The glomerular mesangial expansion in the high-dose mizoribine-treated ddY mice was milder than that found in the control ddY mice. In 45-week-old ddY mice, the average number of intraglomerular cells in the high-dose and low-dose mizoribine-treated ddY mice was slightly lower than that in drinking water treated ddY mice. The levels of urinary protein excretion in the high-dose mizoribine-treated ddY mice were also lower than those in the low-dose mizoribine-treated or drinking water treated ddY mice. It appears that treatment of mizoribine might influence the proliferation of B cells, especially IgA-bearing B cells, and improve the glomerular IgA deposition and glomerular expansion in early-stage IgA nephropathy of ddY mice.

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          Author and article information

          S. Karger AG
          May 1998
          29 April 1998
          : 79
          : 1
          : 67-72
          Departments of a Medicine, Division of Nephrology, and b Pathology, Juntendo University School of Medicine, Tokyo, Japan
          44994 Nephron 1998;79:67–72
          © 1998 S. Karger AG, Basel

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          Page count
          Figures: 4, References: 18, Pages: 6
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/44994
          Original Paper

          Cardiovascular Medicine, Nephrology

          Mizoribine, immunosuppression, IgA nephropathy, ddY mouse


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