Blog
About

8
views
0
recommends
+1 Recommend
1 collections
    4
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      ULTRASTRUCTURAL RESEARCH OF THE ENDOMETRIUM RECEPTIVITY IN CONDITIONS OF PRE-CONCEPTIONAL PREPARATION IN REFRACTORY PREGNANCY LOSS

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background. Refractory pregnancy loss (RPL) is a multifactoral pathology in women of reproductive age which treatment represents great difficulties. Great role in RPL pathogenesis is stipulated by chronic endometritis resulting from disturbances of implantation followed by gestational sac malfunction, which is not less significant than progesterone deficiency. Objective. The aim of research was to study the dynamics of ultrastructural changes of endometric epithelial cells in the conditions of pre-conception preparation in refractory pregnancy loss. Methods. 63 samples of endometrium bioptates obtained from female patients of reproductive age with insufficient middle luteal phase of the cycle were studied. Light and electronic microscopy was used to study the morphological changes in endometric epithelial cells. Results. Pre-conceptional cyclic hormone therapy (1 mg 17-estradiol and 20 mg of didrogesteron) in comparison with monotherapy of 20 mg of didrogesteron during 3 months contributed to intracellular regeneration and restoration of secretor phenotype of endometrium epithelial cells corresponding to the status of receptivity with “opened window of implantation”. Conclusions. Cyclic hormonotherapy in combination with complex metabolic therapy as a pre-conceptional preparation contributing to pregnancy illustrates much higher effectiveness of pathogenetically proved preconceptional hormonotherapy KEY WORDS: refractory pregnancy loss, endometrium receptivity, hormone therapy, ultrastructure.

          Related collections

          Author and article information

          Journal
          International Journal of Medicine and Medical Research
          Ukrmedknyha
          01 December 2014
          : 1
          : 1
          Affiliations
          [1 ] State Budget Educational Institution of Higher Professional Education "Novosibirsk State Medical University" of the Ministry of Public Health
          Article
          edc44da2ef4b4853b2a6fb5e8590e7e4
          10.11603/ijmmr.2413-6077.2015.1.2852

          This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

          Categories
          Medicine
          R

          Comments

          Comment on this article