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      Evaluating the affective component of the cerebellar cognitive affective syndrome.

      The Journal of neuropsychiatry and clinical neurosciences
      Anxiety, epidemiology, pathology, Cerebellar Diseases, psychology, Cognition Disorders, Depression, Humans, Mood Disorders, Spinocerebellar Ataxias, Syndrome

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          Abstract

          The authors performed a systematic review and meta-analysis of studies evaluating the affective component of the cerebellar cognitive affective syndrome. Depressive and anxiety symptoms and personality changes were more frequent in patients with spinocerebellar ataxia. Patients with cerebellar lesions were more likely to have depression, deficits in the ability to experience emotions, and behavioral difficulties. A meta-analysis revealed modestly higher scores on the Hamilton Depression Rating Scale (HAM-D) among patients with cerebellar disease. This review highlights the need for cohort studies using noncerebellar comparison groups, more sensitive measures, and appropriate-sized populations with isolated cerebellar lesions to thoroughly assess the affective component of the cerebellar cognitive affective syndrome.

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          Author and article information

          Journal
          19776302
          10.1176/appi.neuropsych.21.3.245

          Chemistry
          Anxiety,epidemiology,pathology,Cerebellar Diseases,psychology,Cognition Disorders,Depression,Humans,Mood Disorders,Spinocerebellar Ataxias,Syndrome

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