Effect of Furosemide on the Urinary Excretion of Some Plasma Proteins

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Abstract

In 30 patients with a variety of glomerular renal disorders, intravenously administered furosemide was associated with a significant increase of the urinary excretion of the protein fraction with a molecular weight higher than 50,000. The excretion of protein with a molecular weight less than 50,000 was not altered. In relation to endogenous clearance of creatinine the clearance of transferrin, IgG and α<sub>2</sub>-macroglobulin increased significantly. In relation to transferrin clearance, the clearance values of albumin and IgG remained unchanged, whereas that of α<sub>2</sub>-macroglobulin increased significantly. These results support the view that furosemide increases the permeability of the glomerular capillary for serum proteins.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1978

Publication date (Print): 1978

Publication date (Electronic): 02 December 2008

Volume: 22

Issue: 4-6

Pages: 551-557

Affiliations

Fourth Department of Medicine, University Central Hospital, Helsinki, and Department of Clinical Sciences, University of Tampere, Tampere

Article

Publisher ID: 181533 Other ID: Nephron 1978;22:551–557

DOI: 10.1159/000181533

PubMed ID: 84347

SO-VID: 2e9689aa-80d2-43bc-913b-dfb1b3b205a0

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 27 June 1977

Date accepted : 21 November 1977

Page count

Pages: 7

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