Logistic regression analysis of influencing factors related to loss of follow-up in patients treated with HAART

Abstract

Objective To explore the related factors of missing visit in AIDS patients treated with antiviral therapy, for providing basis for the management of HIV patients.

Methods Totally 200 cases of missing HIV/AIDS patients with antiviral therapy were taken as the observation group, and the unlost visitors as the control group in the Fourth People’s Hospital of Nanning from June 2005 to December 2018, using logistic regression analysis of the relationship between 12 factors and lost visit. These 12 factors include gender, age, baseline CD4 ⁺T lymphocyte count, route of transmission, baseline disease stage, the stage of disease, the last CD4 T lymphocyte count, pick up your own medicine, marital status, number of children, regions, side effects.

Results Totally 85 cases (42.5%) were lost within 12 months by HAART, and 123 cases (61.5%) were lost within 24 months. The 12 factors were analyzed by multivariate Logistic regression analysis, finally entered the regression model for transmission, the last CD4 ⁺T lymphocytes, adverse drug reaction, the adjustment of the value of OR and OR95% CI were 6.26(2.99-13.10), 8.68(4.32-17.45), 10.52(2.77-40.00).

Conclusions Most of the loss of HAART treatment in HIV/AIDS patients occurred within 2 years of the beginning of treatment. Patients with side effects to HAART treatment should be treated or replaced in a timely manner. We should strengthen the individual guidance and warning education for injecting drug use and HIV/AIDS who is not ideal in CD4 T lymphocyte elevation after treatment. Increase patient confidence in treatment and reduce the occurrence of loss of visit.

Abstract

摘要： 目的 探讨艾滋病抗病毒治疗患者失访发生的相关影响因素,为HIV/AIDS患者管理提供依据。 方法 收集 2005年6月—2018年12月在南宁市第四人民医院进行抗病毒治疗的艾滋病抗病毒治疗患者为研究对象, 使用Excel的 RAND随机函数生成的随机数字由小到大进行排序, 选取排序前200例的HAART失访的患者为观察组, 对照组为在治 疗的艾滋病患者中随机选取的200例。采用Logistic回归分析方法分析患者性别、年龄、基线CD4+T淋巴细胞计数、传 播途径、基线疾病分期、目前疾病分期、最近1次CD4+T淋巴细胞计数、领药、婚姻状况、子女人数、地区、药物不良反应 等12项因素与失访的关系。 结果观察组接受HAART 12个月内失访85例, 占总失访人数的42.5%, 24个月内失访 123例, 占总失访人数的61.5%。将12个因素进行多因素logistic回归分析, 最终进入回归模型的因素为传播途径、最近 1次CD4+T淋巴细胞、药物不良反应, 其调整的 OR 值及 OR95% CI 分别为6.26(2.99～13.10)、8.68(4.32～17.45)、10.52(2.77 ～40.00)。 结论HIV/AIDS患者HAART 失访大部分发生在开始治疗的2年内, 对出现HAART有不良反应的患者进行 及时处理或更换治疗方案, 强化对注射吸毒、治疗后CD4+T淋巴细胞提升不理想HIV/AIDS感染者的个体指导和警示教 育, 增强患者治疗信心, 减少失访的发生。

Journal

Journal ID (publisher-id): CTM

Title: China Tropical Medicine

Publisher: China Tropical Medicine (China )

ISSN (Electronic): 1009-9727

Publication date (Print): 01 November 2019

Publication date (Electronic): 01 January 2020

Volume: 19

Issue: 11

Pages: 1044-1047

Affiliations

¹AIDS Clinical Treatment Center of Guangxi (Nanning), Nanning Fourth People’s Hospital, Nanning, Guangxi 530023, China

Article

Publisher ID: j.cnki.46-1064/r.2019.11.09

DOI: 10.13604/j.cnki.46-1064/r.2019.11.09

Copyright statement: © 2019 Editorial Department of China Tropical Medicine

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Subject: Journal Article