14
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Preparation and swelling properties of pH-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release

      , , , ,
      International Journal of Biological Macromolecules
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A series of pH-sensitive composite hydrogel beads, chitosan-g-poly (acrylic acid)/vermiculite/sodium alginate (CTS-g-PAA/VMT/SA), was prepared using CTS-g-PAA/VMT composite and SA by Ca(2+) as the crosslinking agent. The structure and morphologies of the developed composite hydrogel beads were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The swelling properties and pH-sensitivity of the beads were investigated. In addition, the drug loading and controlled release behaviors of the beads were also evaluated using diclofenac sodium (DS) as the model drug in stimulated gastric fluids (pH 2.1) and intestinal fluids (pH 6.8). The results indicate that the composite hydrogel beads showed good pH-sensitivity. The release rate of the drug from the composite hydrogel beads is remarkably slowed down, which indicated that incorporating VMT into the composite hydrogel beads can improve the burst release effect of the drug.

          Related collections

          Author and article information

          Journal
          International Journal of Biological Macromolecules
          International Journal of Biological Macromolecules
          Elsevier BV
          01418130
          April 2010
          April 2010
          : 46
          : 3
          : 356-362
          Article
          10.1016/j.ijbiomac.2010.01.009
          20096301
          2ea671ee-3ec2-4a07-8bb2-6b72b62e3ee4
          © 2010

          https://www.elsevier.com/tdm/userlicense/1.0/

          History

          Comments

          Comment on this article