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      Basic science and clinical aspects of wound healing in glaucoma filtering surgery.

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          Abstract

          Success of glaucoma filtration surgery is influenced by the wound healing response. Attention has been focused on pharmacological agents to control a process that leads to excessive scarring and eventual failure of glaucoma filtration surgery. Several agents, including 5-fluorouracil and mitomycin C, as well as other antiproliferative drugs will be discussed. Newer antifibrotic agents and novel drug delivery systems are under development in tissue culture and animal models in an effort to improve efficacy and safety. This article summarizes current treatment modalities and future prospects to prevent excessive wound healing and improve the success of glaucoma filtration surgery.

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          Author and article information

          Journal
          J Ocul Pharmacol Ther
          Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
          1080-7683
          1080-7683
          Feb 1998
          : 14
          : 1
          Affiliations
          [1 ] Jules Stein Eye Institute, Department of Opthalmology, UCLA School of Medicine, Los Angeles, California 90095-7004, USA.
          Article
          10.1089/jop.1998.14.75
          9493785
          2ed336e4-cb13-454c-8262-61f6f8c87566
          History

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