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      Increased Serum Prolactin and Excessive Daytime Sleepiness: An Attempt of Proof-of-Concept Study.

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          Abstract

          The objectives of this study were: (1) to identify subjects with hyperprolactinemia in a clinical sample of patients; (2) to compare the neurologic, psychiatric, and sleep conditions found in patients subgrouped by excessive daytime sleepiness (EDS) and hyperprolactinemia; and (3) to identify patients with hyperprolactinemia and EDS not supported by the presence of any other neurologic, psychiatric, or sleep disorder, or substance/medication use. A retrospective chart review of inpatients was carried out in order to identify all patients in whom the prolactin (PRL) serum levels were determined. A total of 130 subjects were retrieved: 55 had increased levels of PRL, while the remaining 75 participants had normal PRL levels. EDS was reported by 32 (58.2%) participants with increased PRL and 34 (45.3%) with normal PRL. Obstructive sleep apnea or other sleep or neurologic/psychiatric conditions could explain EDS in all participants with normal PRL. Among subjects with increased PRL, eight had no other neurologic/psychiatric or sleep disorder (or drug) potentially causing EDS; these participants, at polysomnography, had time in bed, sleep period time, and total sleep time longer than those with EDS associated to another condition. These findings can be considered as a preliminary indication of a role of hyperprolactinemia in EDS and represent a basis for future controlled studies able to test this hypothesis in a reliable, objective, and methodologically more appropriate way.

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          Author and article information

          Journal
          Brain Sci
          Brain sciences
          MDPI AG
          2076-3425
          2076-3425
          Nov 28 2021
          : 11
          : 12
          Affiliations
          [1 ] Istituti Clinici Scientifici Maugeri, IRCCS, Scientific Institute of Pavia, 27100 Pavia, Italy.
          [2 ] Department of Neurology I.C., Oasi Research Institute-IRCCS, 94018 Troina, Italy.
          [3 ] Department of Surgery and Medical-Surgery Specialties, University of Catania, 95123 Catania, Italy.
          [4 ] Division of Pulmonary and Sleep Medicine, Seattle Children's Hospital, 4800 Sand Point Way, Seattle, WA 98105, USA.
          [5 ] IRCCS, Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
          [6 ] Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.
          [7 ] Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
          Article
          brainsci11121574
          10.3390/brainsci11121574
          8699448
          34942875
          2ed84367-2fc3-446f-8eaa-e010664e915c
          History

          excessive daytime sleepiness,hypersomnia,observational study,prolactin,sleep disorders,comorbidity

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