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      Malondialdehyde-Modified LDL IgG Antibody Levels and Indices of Cardiac Function in Valvular Heart and Coronary Artery Disease Patients

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          Abstract

          Objective

          To compare the changes in anti-malondialdehyde-modified low-density lipoprotein (MDA-LDL) IgG levels among patients undergoing off-pump and on-pump coronary artery bypass grafting (CABG) or valvuloplasty.

          Subjects and Methods

          A total of 38, 39 and 34 patients who underwent off-pump CABG, on-pump CABG and valvuloplasty, respectively, were enrolled in this study. Serum anti-MDA-LDL IgG values were measured 24 h before and after the operative procedures and at discharge. Echocardiography was also done before surgery and before discharge. The results were compared with values from 50 healthy controls.

          Results

          In all patients, a reduction in antibody titers was observed post-operatively. However, the decrease was significant only in the off-pump CABG–before surgery: 42.33 (25.83–58.51), after surgery: 30.86 (16.36–51.33) and at discharge: 10.96 (6.82–23.57; p = 0.027). There was a significant positive association between anti-MDA-LDL IgG levels and ejection fraction (r = 0.248, p = 0.036) and a negative association with E/E', a marker of pulmonary capillary wedge pressure, in the coronary patients (r = −0.345, p = 0.012), but no significant associations were found in patients with valvular heart disease.

          Conclusions

          Serum anti-MDA-LDL IgG levels were associated with cardiac function indices in coronary patients undergoing CABG.

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          Most cited references29

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          Role of oxidative stress in atherosclerosis

          David K Harrison, Kathy K. Griendling, Ulf Landmesser … (2003)
          Article 0 comments Cited 190 times – based on 0 reviews     Review now
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            New Doppler echocardiographic applications for the study of diastolic function.

            Mario García, James D Thomas, Allan L Klein (1998)
            Doppler echocardiography is one of the most useful clinical tools for the assessment of left ventricular (LV) diastolic function. Doppler indices of LV filling and pulmonary venous (PV) flow are used not only for diagnostic purposes but also for establishing prognosis and evaluating the effect of therapeutic interventions. The utility of these indices is limited, however, by the confounding effects of different physiologic variables such as LV relaxation, compliance and filling pressure. Since alterations in these variables result in changes in Doppler indices of opposite direction, it is often difficult to determine the status of a given variable when a specific Doppler filling pattern is observed. Recently, color M-mode and tissue Doppler have provided useful insights in the study of diastolic function. These new Doppler applications have been shown to provide an accurate estimate of LV relaxation and appear to be relatively insensitive to the effects of preload compensation. This review will focus on the complementary role of color M-mode and tissue Doppler echocardiography and traditional Doppler indices of LV filling and PV flow in the assessment of diastolic function.
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              Oxygen free radicals and congestive heart failure.

              M. Chopra, J. Belch, Sasinya N Scott … (1991)
              Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly higher in the patients with congestive heart failure (median 9.0 nmol/ml interquartile range (IQR) 7.9-10.2) than in the controls (median 7.7 nmol/ml (IQR 6.9-9.2)). Plasma thiols were significantly lower in congestive heart failure (median 420 mumol/l (IQR 379-480)) than in the controls (median 463 mumol/l (IQR 445-525)). There was a significant but weak negative correlation between malondialdehyde and left ventricular ejection fraction (r = -0.35) and a positive correlation between plasma thiols and left ventricular ejection fraction (r = 0.39). This study provides clinical support for experimental data indicating that free radicals may be important in heart failure. It also suggests that the degree of free radical production may be linked to the severity of the disease.
              Article 0 comments Cited 68 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Med Princ Pract
                Journal ID (iso-abbrev): Med Princ Pract
                Journal ID (publisher-id): MPP
                Title: Medical Principles and Practice
                Publisher: S. Karger AG (Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch )
                ISSN (Print): 1011-7571
                ISSN (Electronic): 1423-0151
                Publication date (Print): July 2015
                Publication date (Electronic): 26 June 2015
                Publication date PMC-release: 26 June 2015
                Volume: 24
                Issue: 5
                Pages: 424-431
                Affiliations
                [1] aBiochemistry of Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
                [2] bCardiovascular Research Center, School of Medicine, Mashhad, Iran
                [3] cDepartment of Cardiovascular Surgery, Ghaem Hospital, Mashhad, Iran
                [4] dBiotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
                [5] eDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
                [6] fBrighton and Sussex Medical School, Division of Medical Education, Falmer, UK
                [7] gMetabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, W.A., Australia
                Author notes
                *Majid Ghayour-Mobarhan, Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad 9177948564 (Iran), E-Mail ghayourm@ 123456mums.ac.ir
                Article
                Publisher ID: mpp-0024-0424
                DOI: 10.1159/000431178
                PMC ID: 5588258
                PubMed ID: 26139161
                SO-VID: 2ed856c0-8d91-479d-a838-9b67397ac837
                Copyright © Copyright © 2015 by S. Karger AG, Basel
                License:

                This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.

                History
                Date received : 5 November 2014
                Date accepted : 6 May 2015
                Page count
                Figures: 2, Tables: 2, References: 30, Pages: 8
                Categories
                Subject: Original Paper

                Keywords: anti-malondialdehyde-modified low-density lipoprotein,valvular heart disease,coronary artery bypass grafting,cardiac function
                Data availability:
                Keywords: anti-malondialdehyde-modified low-density lipoprotein, valvular heart disease, coronary artery bypass grafting, cardiac function

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