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      • Record: found
      • Abstract: found
      • Article: found

      Investigation of the Use of Positron Emission Tomography for Neuroreceptor Imaging in Rabbit Eyes

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          To determine whether positron emission tomography (PET) can be used for imaging of neuroreceptors in eyes of rabbits. PET imaging of dopamine D<sub>2</sub> receptor, dopamine transporter, serotonin<sub>1A</sub> receptor and sigma<sub>1</sub> receptor in the eyes and brain was performed using corresponding positron-emitting ligands in baseline, pretreatment and displacement conditions. The 4 radioligands outlined the eyes and brain in the baseline. Pretreatment resulted in a slight reduction (26–28%) in the uptake in the anterior segments of eyes. The binding of each radioligand in the iris-ciliary body and retina was confirmed by ex vivo autoradiography. However, the PET signal in the eyes was unexpectedly higher than the autoradiography signal. The identification of radioligand-neuroreceptor binding by PET in the rabbit eyes is not specific enough.

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          MicroPET: a high resolution PET scanner for imaging small animals

          M. Andreaco, M.J. Paulus, D.M. Binkley … (1997)
          Article 0 comments Cited 84 times – based on 0 reviews     Review now
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            Localization of adenosine receptor messenger RNAs in the rat eye.

            A Kvanta, S Seregard, B B Fredholm … (1997)
            Adenosine is present in all cells and body fluids and has been suggested to play several roles in the physiology of ocular tissues. The present study was undertaken to determine which types of adenosine receptor mRNAs are present in the rat eye, and where they are expressed. RNA or deoxyoligodeoxynucleotides complementary to rat adenosine receptor subtypes A1, A2A, A2B and A3 were used to generate 35S labeled antisense and sense probes. The probes were then used for in situ hybridization on 10 microm cryosections of the rat eye including the cornea, iris, ciliary body, lens, retina, choroid and sclera. A1, A2A and A2B receptor mRNAs were demonstrated in the ciliary processes. A1 receptor mRNA was also expressed in the ganglion cell layer of the retina. The retina also showed A2A receptor mRNA expression, which was most prominent in the inner nuclear layer and less prominent in the ganglion cell layer and outer nuclear layer. Weak A2A expression was found in the retinal pigment epithelium and choriocapillaris. No significant expression of A3 receptor mRNA was found in the rat eye. In conclusion, using in situ hybridization, we have demonstrated expression of mRNA for A1, A2A and A2B adenosine receptors in the rat eye. The expression patterns support specific roles for adenosine in the ciliary process and retina. Copyright 1997 Academic Press Limited.
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              A high resolution PET for animal studies

              T Yamashita, T Ohmura, E Yoshikawa … (1992)
              Article 0 comments Cited 16 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): ORE
                Journal ID (nlm-ta): Ophthalmic Res
                Journal ID (doi): 10.1159/issn.0030-3747
                Title: Ophthalmic Research
                Publisher: S. Karger AG
                ISSN (Print): 0030-3747
                ISSN (Electronic): 1423-0259
                Publication date Subscription-year: 2004
                Publication date (Print): October 2004
                Publication date (Electronic): 26 November 2004
                Volume: 36
                Issue: 5
                Pages: 255-263
                Affiliations
                aPositron Medical Center, Tokyo Metropolitan Institute of Gerontology, and bDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, cNara Research and Development Center, Santen Pharmaceutical Company Ltd., Nara, and dM’s Sciences Company, Kobe, Japan
                Article
                Publisher ID: 81205 Other ID: Ophthalmic Res 2004;36:255–263
                DOI: 10.1159/000081205
                PubMed ID: 15583431
                SO-VID: 2eebdf7c-2010-4347-bec3-73d0677dd1d5
                Copyright © © 2004 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Date received : 12 June 2003
                Date accepted : 20 April 2004
                Page count
                Figures: 4, Tables: 1, References: 44, Pages: 9
                Categories
                Subject: Original Paper

                ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
                Keywords: Positron emission tomography,Iris-ciliary body,Rabbit,Retina,Neuroreceptor
                Data availability:
                ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
                Keywords: Positron emission tomography, Iris-ciliary body, Rabbit, Retina, Neuroreceptor

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