Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Coffee consumption has been linked to lower risk of various health outcomes. However, the biological pathways mediating the associations remain poorly understood. The aim of this study was to assess the association between coffee consumption and concentrations of plasma biomarkers in key metabolic and inflammatory pathways underlying common chronic diseases. We investigated the associations of total, caffeinated, and decaffeinated coffee consumption with 14 plasma biomarkers, including C-peptide, insulin-like growth factor 1 (IGF-1), IGF binding protein (IGFBP) 1, IGFBP-3, estrone, total and free estradiol, total and free testosterone, sex hormone–binding globulin (SHBG), total adiponectin, high-molecular-weight (HMW) adiponectin, leptin, C-reactive protein (CRP), interleukin 6 (IL-6), and soluble tumor necrosis factor receptor 2 (sTNFR-2). Data were derived from 2 cohorts of 15,551 women (Nurses’ Health Study) and 7397 men (Health Professionals Follow-Up Study), who provided detailed dietary data before blood draw and were free of diabetes, cardiovascular disease, or cancer at the time of blood draw. Multivariable linear regression was used to calculate the percentage difference of biomarker concentrations comparing coffee drinkers with nondrinkers, after adjusting for a variety of demographic, clinical, and lifestyle factors. Compared with nondrinkers, participants who drank ≥4 cups of total coffee/d had lower concentrations of C-peptide (−8.7%), IGFBP-3 (−2.2%), estrone (−6.4%), total estradiol (−5.7%), free estradiol (−8.1%), leptin (−6.4%), CRP (−16.6%), IL-6 (−8.1%), and sTNFR-2 (−5.8%) and higher concentrations of SHBG (5.0%), total testosterone (7.3% in women and 5.3% in men), total adiponectin (9.3%), and HMW adiponectin (17.2%). The results were largely similar for caffeinated and decaffeinated coffee. Our data indicate that coffee consumption is associated with favorable profiles of numerous biomarkers in key metabolic and inflammatory pathways. This trial was registered at clinicaltrials.gov as NCT03419455.

Related collections

Most cited references 48

Record: found
Abstract: found
Article: not found

Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption.

S Salvini, D J Hunter, L. Sampson … (1989)

The reproducibility and validity of responses for 55 specific foods and beverages on a self-administered food frequency questionnaire were evaluated. One hundred and seventy three women from the Nurses' Health Study completed the questionnaire twice approximately 12 months apart and also recorded their food consumption for seven consecutive days, four times during the one-year interval. For the 55 foods, the mean of correlation coefficients between frequencies of intake for first versus second questionnaire was 0.57 (range = 0.24 for fruit punch to 0.93 for beer). The mean of correlation coefficients between the dietary records and first questionnaire was 0.44 (range = 0.09 for yellow squash to 0.83 for beer and tea) and between the dietary records and the second questionnaire was 0.52 (range = 0.08 for spinach to 0.90 for tea). Ratios of within- to between-person variance for the 55 foods were computed using the mean four one-week dietary records for each person as replicate measurements. For most foods this ratio was greater than 1.0 (geometric mean of ratios = 1.88), ranging from 0.25 (skimmed milk) to 14.76 (spinach). Correlation coefficients comparing questionnaire and dietary record for the 55 foods were corrected for the within-person variation (mean corrected value = 0.55 for dietary record versus first questionnaire and 0.66 versus the second). Mean daily amounts of each food calculated by the questionnaire and by the dietary record were also compared; the observed differences suggested that responses to the questionnaire tended to over-represent socially desirable foods. This analysis documents the validity and reproducibility of the questionnaire for measuring specific foods and beverages, as well as the large within-person variation for food intake measured by dietary records. Differences in the degree of validity for specific foods revealed in this type of analysis can be useful in improving questionnaire design and in interpreting findings from epidemiological studies that use the instrument.

0 comments Cited 305 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Insulin-like growth factors and neoplasia.

Michael Pollak, Eva Schernhammer, Susan E Hankinson (2004)

0 comments Cited 276 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Inflammatory markers and the risk of coronary heart disease in men and women.

Jennifer K Pai, Tobias Pischon, Jing Ma … (2004)

Few studies have simultaneously investigated the role of soluble tumor necrosis factor alpha (TNF-alpha) receptors types 1 and 2 (sTNF-R1 and sTNF-R2), C-reactive protein, and interleukin-6 as predictors of cardiovascular events. The value of these inflammatory markers as independent predictors remains controversial. We examined plasma levels of sTNF-R1, sTNF-R2, interleukin-6, and C-reactive protein as markers of risk for coronary heart disease among women participating in the Nurses' Health Study and men participating in the Health Professionals Follow-up Study in nested case-control analyses. Among participants who provided a blood sample and who were free of cardiovascular disease at baseline, 239 women and 265 men had a nonfatal myocardial infarction or fatal coronary heart disease during eight years and six years of follow-up, respectively. Using risk-set sampling, we selected controls in a 2:1 ratio with matching for age, smoking status, and date of blood sampling. After adjustment for matching factors, high levels of interleukin-6 and C-reactive protein were significantly related to an increased risk of coronary heart disease in both sexes, whereas high levels of soluble TNF-alpha receptors were significant only among women. Further adjustment for lipid and nonlipid factors attenuated all associations; only C-reactive protein levels remained significant. The relative risk among all participants was 1.79 for those with C-reactive protein levels of at least 3.0 mg per liter, as compared with those with levels of less than 1.0 mg per liter (95 percent confidence interval, 1.27 to 2.51; P for trend <0.001). Additional adjustment for the presence or absence of diabetes and hypertension moderately attenuated the relative risk to 1.68 (95 percent confidence interval, 1.18 to 2.38; P for trend = 0.008). Elevated levels of inflammatory markers, particularly C-reactive protein, indicate an increased risk of coronary heart disease. Although plasma lipid levels were more strongly associated with an increased risk than were inflammatory markers, the level of C-reactive protein remained a significant contributor to the prediction of coronary heart disease. Copyright 2004 Massachusetts Medical Society.

0 comments Cited 218 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: The American Journal of Clinical Nutrition

Publisher: Oxford University Press (OUP)

ISSN (Print): 0002-9165

ISSN (Electronic): 1938-3207

Publication date Created: March 2019

Publication date Created: March 01 2019

Publication date Created: March 05 2019

Publication date Other: March 2019

Publication date (Print): March 01 2019

Publication date (Electronic): March 05 2019

Volume: 109

Issue: 3

Pages: 635-647

Affiliations

[1 ]Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China

[2 ]Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA

[3 ]Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

[4 ]Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA

[5 ]Department of Epidemiology, Richard M Fairbanks School of Public Health, Indiana University, and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN

[6 ]Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA

[7 ]Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, MA

[8 ]Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA

[9 ]Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

Article

DOI: 10.1093/ajcn/nqy295

PMC ID: 6408210

PubMed ID: 30834441

SO-VID: 2efa0eb3-399a-4fd6-8c90-3da50658699b

License:

https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model

Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals

Read this article at

Abstract

Related collections

Biomarkers for Inflammatory Lung Disease

Most cited references 48

Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption.

Insulin-like growth factors and neoplasia.

Inflammatory markers and the risk of coronary heart disease in men and women.

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 1,132

Cited by 36

Most referenced authors 913