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      2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC).

      1 , 1 , , , , , , , , , , , , , , , , , , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2 , 2
      European heart journal
      Acute cardiac care, Acute coronary syndromes, Angioplasty, Anticoagulation, Apixaban, Aspirin, Atherothrombosis, Beta-blockers, Bivalirudin, Bypass surgery, Cangrelor, Chest pain unit, Clopidogrel, Dabigatran, Diabetes, Early invasive strategy, Enoxaparin, European Society of Cardiology, Fondaparinux, Glycoprotein IIb/IIIa inhibitors, Guidelines, Heparin, High-sensitivity troponin, Myocardial ischaemia, Nitrates, Non-ST-elevation myocardial infarction, Platelet inhibition, Prasugrel, Recommendations, Revascularization, Rhythm monitoring, Rivaroxaban, Statin, Stent, Ticagrelor, Unstable angina, Vorapaxar

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          2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism.

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            Predictors of hospital mortality in the global registry of acute coronary events.

            Management of acute coronary syndromes (ACS) should be guided by an estimate of patient risk. To develop a simple model to assess the risk for in-hospital mortality for the entire spectrum of ACS treated in general clinical practice. A multivariable logistic regression model was developed using 11 389 patients (including 509 in-hospital deaths) with ACS with and without ST-segment elevation enrolled in the Global Registry of Acute Coronary Events (GRACE) from April 1, 1999, through March 31, 2001. Validation data sets included a subsequent cohort of 3972 patients enrolled in GRACE and 12 142 in the Global Use of Strategies to Open Occluded Coronary Arteries IIb (GUSTO-IIb) trial. The following 8 independent risk factors accounted for 89.9% of the prognostic information: age (odds ratio [OR], 1.7 per 10 years), Killip class (OR, 2.0 per class), systolic blood pressure (OR, 1.4 per 20-mm Hg decrease), ST-segment deviation (OR, 2.4), cardiac arrest during presentation (OR, 4.3), serum creatinine level (OR, 1.2 per 1-mg/dL [88.4- micro mol/L] increase), positive initial cardiac enzyme findings (OR, 1.6), and heart rate (OR, 1.3 per 30-beat/min increase). The discrimination ability of the simplified model was excellent with c statistics of 0.83 in the derived database, 0.84 in the confirmation GRACE data set, and 0.79 in the GUSTO-IIb database. Across the entire spectrum of ACS and in general clinical practice, this model provides excellent ability to assess the risk for death and can be used as a simple nomogram to estimate risk in individual patients.
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              Platelet activation and atherothrombosis.

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                Author and article information

                Journal
                Eur. Heart J.
                European heart journal
                1522-9645
                0195-668X
                Jan 14 2016
                : 37
                : 3
                Affiliations
                [1 ] Marco.Roffi@hcuge.ch.
                [2 ] The disclosure forms of all experts involved in the development of these guidelines are available on the ESC website http://www.escardio.org/guidelines.
                Article
                ehv320
                10.1093/eurheartj/ehv320
                26320110
                2f0154d1-5212-48c2-9093-c65c5a839016

                Acute cardiac care,Acute coronary syndromes,Angioplasty,Anticoagulation,Apixaban,Aspirin,Atherothrombosis,Beta-blockers,Bivalirudin,Bypass surgery,Cangrelor,Chest pain unit,Clopidogrel,Dabigatran,Diabetes,Early invasive strategy,Enoxaparin,European Society of Cardiology,Fondaparinux,Glycoprotein IIb/IIIa inhibitors,Guidelines,Heparin,High-sensitivity troponin,Myocardial ischaemia,Nitrates,Non-ST-elevation myocardial infarction,Platelet inhibition,Prasugrel,Recommendations,Revascularization,Rhythm monitoring,Rivaroxaban,Statin,Stent,Ticagrelor,Unstable angina,Vorapaxar

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