In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases
of severe acute respiratory syndrome (SARS). The sequence of the complete genome of
SARS-CoV was determined, and the initial characterization of the viral genome is presented
in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11
open reading frames, and its genome organization is similar to that of other coronaviruses.
Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely
related to any of the previously characterized coronaviruses.