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      Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

      Science

      American Association for the Advancement of Science (AAAS)

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          Abstract

          In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.

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          Author and article information

          Journal
          Science
          American Association for the Advancement of Science (AAAS)
          00368075
          10959203
          May 1 2003
          May 30 2003
          : 300
          : 5624
          : 1394-1399
          Article
          10.1126/science.1085952
          12730500
          © 2003

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