Severe Fever with Thrombocytopenia Syndrome Virus, Shandong Province, China

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Abstract

Severe fever with thrombocytopenia syndrome, which results in severe illness and has a high case-fatality rate, is caused by a novel bunyavirus, severe fever with thrombocytopenia syndrome virus. We found that samples from 2/237 (0.8%) healthy persons and 111/134 (83%) goats in Yiyuan County, Shandong Province, China, were seropositive for this virus.

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A family cluster of infections by a newly recognized bunyavirus in eastern China, 2007: further evidence of person-to-person transmission.

Chang-jun Bao, Xi-ling Guo, Xian Qi … (2011)

Seven persons in one family living in eastern China developed fever and thrombocytopenia during May 2007, but the initial investigation failed to identify an infectious etiology. In December 2009, a novel bunyavirus (designated severe fever with thrombocytopenia syndrome bunyavirus [SFTSV]) was identified as the cause of illness in patients with similar clinical manifestations in China. We reexamined this family cluster for SFTSV infection. We analyzed epidemiological and clinical data for the index patient and 6 secondary patients. We tested stored blood specimens from the 6 secondary patients using real time reverse transcription polymerase chain reaction (RT-PCR), viral culture, genetic sequencing, micro-neutralization assay (MNA), and indirect immunofluorescence assay (IFA). An 80-year-old woman with fever, leucopenia, and thrombocytopenia died on 27 April 2007. Between 3 and 7 May 2007, another 6 patients from her family were admitted to a local county hospital with fever and other similar symptoms. Serum specimens collected in 2007 from these 6 patients were positive for SFTS viral RNA through RT-PCR and for antibody to SFTSV through MNA and IFA. SFTSV was isolated from 1 preserved serum specimen. The only shared characteristic between secondary patients was personal contact with the index patient; none reported exposure to suspected animals or vectors. Clinical and laboratory evidence confirmed that the patients of fever and thrombocytopenia occurring in a family cluster in eastern China in 2007 were caused by a newly recognized bunyavirus, SFTSV. Epidemiological investigation strongly suggests that infection of secondary patients was transmitted to family members by personal contact.

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Journal

Journal ID (nlm-ta): Emerg Infect Dis

Journal ID (iso-abbrev): Emerging Infect. Dis

Journal ID (publisher-id): EID

Title: Emerging Infectious Diseases

Publisher: Centers for Disease Control and Prevention

ISSN (Print): 1080-6040

ISSN (Electronic): 1080-6059

Publication date (Print): June 2012

Volume: 18

Issue: 6

Pages: 963-965

Affiliations

[1]Shandong University School of Public Health, Jinan, China (L. Zhao, H. Wen, Y. Chi, F. Xue, Z. Wang, Y. Song, X-j Yu);

[2]Zibo Municipal Center for Disease Control and Prevention, Zibo, China (S. Zhai, F. Cui, L. Wang, J. Du);

[3]Yiyuan County Center for Disease Control and Prevention, Yiyuan, China (Q. Wang, S. Zhang);

[4]University of Texas Medical Branch, Galveston, Texas, USA (X-j Yu)

Author notes

Address for correspondence: Xue-jie Yu, Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0609, USA; email: xuyu@ 123456utmb.edu

Article

Publisher ID: 11-1345

DOI: 10.3201/eid1806.111345

PMC ID: 3358154

PubMed ID: 22608264

SO-VID: 2f2b2f32-f0be-4a2d-9bf6-a4dd03f536b1

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