19
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Desarrollo y caracterización de micropartículas de ácido fólico formadas por secado por aspersión, utilizando goma arábiga y maltodextrina como materiales de pared Translated title: Development and characterization of folic acid microparticles formed by spray-drying with gum arabic and maltodextrin

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          El ácido fólico es una vitamina esencial, que participa en la biosíntesis de aminoácidos esenciales y en algunos procesos asociados al ADN. Es una vitamina con limitaciones en su estabilidad frente a factores como la luz, pH y oxígeno. Por esta razón se hace necesario desarrollar estrategias que permitan su estabilización sin afectar su actividad biológica. Así pues, se propone la obtención de micropartículas utilizando mezclas de goma arábiga y maltodextrina, con el método de secado por aspersión, que presenten características adecuadas para actuar como un reservorio del ácido fólico con potencialidades para su estabilización. En este estudio se obtienen micropartículas de ácido fólico utilizando cuatro mezclas diferentes de goma arábiga y maltodextrina, caracterizadas mediante los siguientes parámetros: distribución de tamaño de partícula, porcentaje de humedad, morfología, eficiencia de encapsulación y perfil de disolución. Los resultados de la caracterización muestran diferentes aspectos: la morfología de las micropartículas obtenidas por este método varía con la relación goma arábiga- maltodextrina, la eficiencia de encapsulación es elevada para los cuatro tipos de micropartículas estudiadas, la distribución de tamaño de partícula no cambia con la relación de los materiales de la pared y los perfiles de disolución muestran un porcentaje de disolución limitado, siendo el mejor el que corresponde a micropartículas con la relación goma arábiga- maltodextrina 70-30. La goma arábiga es efectiva para el atrapamiento del ácido fólico y cuando se mezcla con maltodextrina se mejoran las características de morfología, eficiencia y disolución de las micropartículas, lo cual sugiere que existe una mezcla óptima de los dos materiales de pared que optimizan las características de las micropartículas.

          Translated abstract

          The folic acid is an essential vitamin, it is involved in the essential aminoacids biosynthesis and some process associated to DNA. Folic acid undergoes degradation reactions when is exposed to light, acid or alkaline medium and oxygen atmosphere. For this reason it is necessary to develop strategies to improve its stability not affecting its biological activity. In this connection the obtaining of microparticles by spray drying, using arabic gum and maltodextrin blends is proposed. The microparticles could act as a carrier of folic acid providing it protection. In this study, microparticles of folic acid were obtained using four different blends of arabic gum and maltodextrin. The particles size distribution, morphology, encapsulation efficiency and dissolution profile were assessed for the different types of microparticles. The results showed different aspects: the microparticles morphology changed with the ratio arabic gum - maltodextrine, the encapsulation efficiency was high for four types of studied microparticles, the particles size distribution did not change with the wall materials ratio, the dissolution profiles showed a limited dissolution percentage, and microparticles of arabic gum-maltodextrin 70-30 showed the best profile. The arabic gum favored the encapsulation of folic acid and when it is mixed with maltodextrin the morphology, encapsulation efficiency and dissolution improved. Probably there is an optimum ratio of two wall materials providing optimum properties to microparticles.

          Related collections

          Most cited references60

          • Record: found
          • Abstract: not found
          • Article: not found

          Applications of spray-drying in microencapsulation of food ingredients: An overview

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Flavour encapsulation and controlled release - a review

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Ultraviolet photodegradation of folic acid.

              The vitamin folate is vital for all living creatures. Scientists have suggested that ultraviolet degradation of folate in vivo played a role in the evolution of mankind. In order to better understand the photodegradation of folate, we have provided a spectroscopic study of the ultraviolet photodegradation of aqueous folic acid under aerobic conditions. We found strong indications that the folic acid molecule is cleaved into p-aminobenzoyl-L-glutamic acid and 6-formyl pterin when exposed to ultraviolet radiation. When the irradiation continues, 6-formyl pterin is degraded to pterin-6-carboxylic acid. The photodegradation of folic acid is divided into three phases. In the first phase, the formation of photoproducts follows a zero order rate law. In the second phase the presence of photoproducts sensitizes the degradation of folic acid and the degradation process is accelerated. In the third phase the degradation of 6-formyl pterin to pterin-6-carboxylic acid is the dominating process. This reaction follows a first order rate law. We show that both 6-formyl pterin and pterin-6-carboxylic acid sensitize the photodegradation of folic acid. However, experiments performed in heavy water indicate that generation of singlet oxygen is probably not the explanation for the photosensitizing of folic acid.
                Bookmark

                Author and article information

                Journal
                vitae
                Vitae
                Vitae
                Facultad de Química Farmacéutica, Universidad de Antioquia (Medellín, Antioquia, Colombia )
                0121-4004
                January 2009
                : 16
                : 1
                : 55-65
                Affiliations
                [01] Medellín orgnameUniversidad de Antioquia orgdiv1Facultad de Química Farmacéutica orgdiv2Grupo de Estudios de Estabilidad de Medicamentos, Cosméticos y Alimentos Colombia
                Article
                S0121-40042009000100007 S0121-4004(09)01600107
                2f3163d0-207e-4bce-a827-308fa54b0a41

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 08 October 2008
                : 30 March 2009
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 38, Pages: 11
                Product

                SciELO Colombia

                Categories
                Producción farmacéutica

                folic acid,maltodextrina,micropartículas,ácido fólico,microparticles,arabic gum,goma arábiga,maltodextrin

                Comments

                Comment on this article

                Similar content401

                Cited by4

                Most referenced authors305