Cytological and immunological changes in bronchoalveolar lavage fluid and histological observation of lung lesions in pigs immunized with Mycoplasma hyopneumoniae inactivated vaccine prepared from broth culture supernate
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Abstract
We have compared the cytology of bronchoalveolar lavage fluid (BALF) and the pathology
of lung lesions in pigs immunized with/without Mycoplasma hyopneumoniae inactivated
vaccine prepared from broth culture supernate on experimental infection. Numbers of
total cells, macrophages, neutrophils and lymphocytes have decreased in BALF of vaccinated
pigs following infection. The mean percentage of lung lesions, inflammatory cell infiltration
into the airways and T cells accumulation around the bronchi were reduced in vaccinated
pigs. The levels of tumor necrosis factor (TNF)-alpha also decreased in vaccinated
pigs. These results suggest that the vaccination may contribute to decrease TNF-alpha
production, and therefore, inflammatory cell responses in the lung due to M. hyopneumoniae
infection were suppressed, resulting in fewer lung lesions.