58
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Serum calcium is associated with dyslipidemia in Korean adults: a cross-sectional study

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Abstract. Objective: The relationship between calcium intake and risk of cardiovascular disease is still debated. The purpose of this study was to investigate the association of calcium intake and serum calcium with dyslipidemia in Korean adults. Methods: This was a population-based, cross-sectional study of 640 subjects (320 men and 320 women) aged 20 – 69 years (average 43.7 years) recruited from eight provinces of South Korea in 2014. Daily calcium intake, serum calcium, and serum lipid profiles of the subjects were analyzed and their correlation was evaluated. Multiple logistic regression analysis was also conducted to calculate odds ratios and 95% confidence intervals (CI) for prevalence of dyslipidemia by serum calcium. Results: Calcium intake was not significantly correlated with serum lipids or calcium. However, serum calcium was positively correlated with serum total cholesterol (p < 0.001) and triglycerides (p < 0.001). The unadjusted prevalence of hypercholesterolemia according to serum calcium tertiles was significantly increased with increments of serum calcium (4.7%, 6.1%, and 12.6% in the T1 – T3 groups; p < 0.005). The unadjusted odds ratio (OR) for having hypercholesterolemia was also significantly increased according to serum calcium tertiles (first tertile reference, third tertile OR = 2.93, 95% CI = 1.38 – 6.22, p for trend < 0.001). The association of serum calcium with the prevalence of hypercholesterolemia was not changed after adjusting for gender, body weight, age, and body mass index. Conclusion: No significant association was found between calcium intake and serum lipid profiles; however, elevated serum calcium within the normal range was shown to be associated with an increased prevalence of dyslipidemia in a Korean cohort.


          Related collections

          Most cited references10

          • Record: found
          • Abstract: found
          • Article: not found

          Regulation of adiposity by dietary calcium.

          Recent data from this laboratory demonstrate that increasing adipocyte intracellular Ca(2+) results in a coordinated stimulation of lipogenesis and inhibition of lipolysis. We have also noted that increasing dietary calcium of obese patients for 1 year resulted in a 4.9 kg loss of body fat (P<0.01). Accordingly, we tested the possibility that calcitrophic hormones may act on adipocytes to increase Ca(2+) and lipid metabolism by measuring the effects of 1, 25-(OH)(2)-D in primary cultures of human adipocytes, and found significant, sustained increases in intracellular Ca(2+) and a corresponding marked inhibition of lipolysis (EC(50) approximately 50 pM; P<0.001), suggesting that dietary calcium could reduce adipocyte mass by suppressing 1,25-(OH)(2)-D. To test this hypothesis, we placed transgenic mice expressing the agouti gene specifically in adipocytes on a low (0.4%) Ca/high fat/high sucrose diet either unsupplemented or with 25 or 50% of the protein replaced by non-fat dry milk or supplemented to 1.2% Ca with CaCO(3) for 6 wk. Weight gain and fat pad mass were reduced by 26-39% by the three high calcium diets (P<0.001). The high calcium diets exerted a corresponding 51% inhibition of adipocyte fatty acid synthase expression and activity (P<0.002) and stimulation of lipolysis by 3. 4- to 5.2-fold (P<0.015). This concept of calcium modulation of adiposity was further evaluated epidemiologically in the NHANES III data set. After controlling for energy intake, relative risk of being in the highest quartile of body fat was set to 1.00 for the lowest quartile of Ca intake and was reduced to 0.75, 0.40, and 0.16 for the second, third, and fourth quartiles, respectively, of calcium intake for women (n=380;P<0.0009); a similar inverse relationship was also noted in men (n=7114; P<0.0006). Thus, increasing dietary calcium suppresses adipocyte intracellular Ca(2+) and thereby modulates energy metabolism and attenuates obesity risk.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Copper and carcinogenesis.

            Metal ions play an important role in biological systems, and without their catalytic presence in trace or ultratrace amounts many essential co-factors for many biochemical reactions would not take place. However, they become toxic to cells when their concentrations surpass certain optimal (natural) levels. Copper is an essential metal. Catalytic copper, because of its mobilization and redox activity, is believed to play a central role in the formation of reactive oxygen species (ROS), such as O2-* and *OH radicals, that bind very fast to DNA, and produce damage by breaking the DNA strands or modifying the bases and/or deoxyribose leading to carcinogenesis. The chemistry and biochemistry of copper is briefly accounted together with its involvement in cancer and other diseases.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Calcium intake, body composition, and lipoprotein-lipid concentrations in adults.

              Recent data suggest that variations in calcium intake may influence lipid metabolism and body composition. The association between daily calcium intake and body composition and plasma lipoprotein-lipid concentrations was studied cross-sectionally in adults from phase 2 of the Québec Family Study. Adults aged 20-65 y (235 men, 235 women) were studied. Subjects who consumed vitamin or mineral supplements were excluded. Subjects were divided into 3 groups on the basis of their daily calcium intake: groups A ( 1000 mg). Daily calcium intake was negatively correlated with plasma LDL cholesterol, total cholesterol, and total:HDL cholesterol in women and men after adjustment for variations in body fat mass and waist circumference (P < 0.05). In women, a significantly greater ratio of total to HDL cholesterol (P < 0.05) was observed in group A than in group C after correction for body fat mass and waist circumference. In women, body weight, percentage body fat, fat mass, body mass index, waist circumference, and total abdominal adipose tissue area measured by computed tomography were significantly greater (P < 0.05) in group A than in groups B and C, even after adjustments for confounding variables. Comparable trends were observed in men, but not after adjustment for the same covariates. A low daily calcium intake is associated with greater adiposity, particularly in women. In both sexes, a high calcium intake is associated with a plasma lipoprotein-lipid profile predictive of a lower risk of coronary heart disease risk compared with a low calcium intake.
                Bookmark

                Author and article information

                Journal
                Trace Elements and Electrolytes
                TE
                Dustri-Verlgag Dr. Karl Feistle
                0946-2104
                2017
                October 01 2017
                : 34
                : 10
                : 159-165
                Article
                10.5414/TEX01486
                2f4ed0c2-8c94-4ef7-8f97-638b0543260a
                © 2017
                History

                Endocrinology & Diabetes,General medicine,Medicine,Gastroenterology & Hepatology,Nutrition & Dietetics
                daily intake,serum concentration,dyslipidemia,calcium,lipid profile

                Comments

                Comment on this article