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      Enhancing the anti-multiple myeloma efficiency in a cancer stem cell xenograft model by conjugating the ABCG2 antibody with microbubbles for a targeted delivery of ultrasound mediated epirubicin.

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          Abstract

          Although multiple myeloma (MM) treatment has improved in the last decade, it remains largely incurable. One of main reasons is that there are cancer stem cells (CSCs) in MM, which are responsible for MM's drug resistance and relapse. In this study, we used the targeting microbubbles (MBs) conjugated with anti-ABCG2 monoclonal antibody (mAb) for ultrasound mediated epirubicin (EPI) delivery to evaluate the therapeutic effectiveness of the novel agent in MM CSC xenograft model.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Biochem. Pharmacol.
          Title: Biochemical pharmacology
          Publisher: Elsevier BV
          ISSN (Electronic): 1873-2968
          ISSN (Print): 0006-2952
          Publication date (Electronic): May 15 2017
          Volume: 132
          Affiliations
          [1 ] Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing 210009, China; Department of Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
          [2 ] Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing 210009, China.
          [3 ] School of Biological Science and Technology, Southeast University, Nanjing 210096, China.
          [4 ] Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing 210009, China. Electronic address: njdoujun@seu.edu.cn.
          Article
          Publisher Item ID: S0006-2952(17)30091-6
          DOI: 10.1016/j.bcp.2017.02.014
          PubMed ID: 28232025
          SO-VID: 2f6af354-f34a-45aa-bcf8-a6b306a4e568
          History

          Keywords: ATP-binding cassette sub-family G member 2,Cancer stem cells,Epirubicin,Microbubble,Multiple myeloma,Ultrasound
          Data availability:
          Keywords: ATP-binding cassette sub-family G member 2, Cancer stem cells, Epirubicin, Microbubble, Multiple myeloma, Ultrasound

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