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      Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial

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          Abstract

          <div class="section"> <a class="named-anchor" id="S1"> <!-- named anchor --> </a> <h5 class="section-title" id="d28927e187">Background &amp; aims</h5> <p id="P1">Indirect comparisons suggest that alternate-day fasting (ADF) may produce greater improvements in body composition, fat distribution, and/or the adipokine profile compared to daily calorie restriction (CR), but this has not been tested directly. In a pre-planned secondary analysis of a randomized controlled trial, we compared changes in the VAT:SAT ratio, FFM:total mass ratio, and the adipokine profile between ADF and CR. </p> </div><div class="section"> <a class="named-anchor" id="S2"> <!-- named anchor --> </a> <h5 class="section-title" id="d28927e192">Methods</h5> <p id="P2">Overweight and obese participants (n = 100) were randomized to 1) ADF (alternating every 24-h between consuming 25% or 125% of energy needs); 2) CR (consuming 75% of needs every day); or 3) control (consuming 100% of needs every day) for 24 wk. </p> </div><div class="section"> <a class="named-anchor" id="S3"> <!-- named anchor --> </a> <h5 class="section-title" id="d28927e197">Results</h5> <p id="P3">The VAT:SAT ratio did not change in any group. The FFM:total mass ratio increased in both ADF (0.03 ± 0.00) and CR (0.03 ± 0.01) compared to the control group (P &lt; 0.01), with no differences between the intervention groups. Circulating leptin decreased in both the ADF group (−18 ± 6%) and CR group (−31 ± 10%) relative to the control group ( <i>P</i> &lt; 0.05), with no differences between the intervention groups. Circulating levels of adiponectin, resistin, IL-6, and TNF-α did not change in either intervention group relative to the control group. </p> </div><div class="section"> <a class="named-anchor" id="S4"> <!-- named anchor --> </a> <h5 class="section-title" id="d28927e205">Conclusion</h5> <p id="P4">ADF and CR similarly improve the FFM:total mass ratio and reduce leptin after a 24-wk intervention. </p> </div>

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          Author and article information

          Journal
          Clinical Nutrition
          Clinical Nutrition
          Elsevier BV
          02615614
          December 2018
          December 2018
          : 37
          : 6
          : 1871-1878
          Article
          10.1016/j.clnu.2017.11.018
          5988907
          29258678
          2f72e4be-a40f-43bd-b440-21b9c931d884
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

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