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      Development of Collaterals in the Cerebral Circulation

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          Sudden occlusion of the middle cerebral artery (MCA) in normotensive rats increases blood flow through anastomosing branches into the territory of the occluded artery. Three weeks after MCA occlusion, anastomoses to anterior cerebral branches are increased by more than 50% in luminal diameter. One month after MCA occlusion, blood flow and blood flow reserve to the territory of the occluded MCA are returned to normal levels. In stroke-prone spontaneously hypertensive rats (SHRSP), the anastomoses are significantly narrower and blood flow through the anastomoses is less than in normotensive rats. Tissue infarction invariably develops in the territory of the occluded MCA in SHRSP. We propose that the luminal width of the anastomosis is a major determinant of blood flow into the territory of the occluded artery and of the amount of tissue protected from infarction by collateral circulation.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 28
          : 1-3
          : 183-189
          aDepartment of Anatomy and Cell Biology, The University of Michigan, Ann Arbor, Mich.; bDepartment of Internal Medicine, The University of Iowa College of Medicine, Iowa City, Iowa, USA
          158860 Blood Vessels 1991;28:183–189
          © 1991 S. Karger AG, Basel

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          Page count
          Pages: 7
          Physiology and Pathophysiology


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