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      Orthogonal Dietary Niche Enables Reversible Engraftment of a Gut Bacterial Commensal

      , , ,
      Cell Reports
      Elsevier BV

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          Abstract

          <p id="P4">Interest in manipulating the gut microbiota to treat disease has led to a need for understanding how organisms can establish themselves when introduced into a host with an intact microbial community. Here, we employ the concept of orthogonal niche engineering: a resource typically absent from the diet, seaweed, creates a customized niche for an introduced organism. In the short term, co-introduction of this resource at 1% in the diet along with an organism with exclusive access to this resource, <i>Bacteroides plebeius</i> DSM 17135, enables it to colonize at a median abundance of 1%, and frequently up to 10 or more percent, both on pulsed and constant seaweed diets. In a two-month follow-up after the initial treatment period, <i>B. plebeius</i> stops responding to seaweed in mice initially on the constant seaweed diet, suggesting treatment regime will affect controllability. These results offer potential for diet-based intervention to introduce and control target organisms. </p><p id="P5"> <div class="figure-container so-text-align-c"> <img alt="" class="figure" src="/document_file/92d2d10f-e3a8-4176-8449-f8bf9d457ddc/PubMedCentral/image/nihms-1043687-f0005.jpg"/> </div> </p>

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          Author and article information

          Journal
          Cell Reports
          Cell Reports
          Elsevier BV
          22111247
          August 2018
          August 2018
          : 24
          : 7
          : 1842-1851
          Article
          10.1016/j.celrep.2018.07.032
          6724203
          30110640
          2f8dca3a-ff09-4b35-ba4c-398d53944912
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

          http://creativecommons.org/licenses/by-nc-nd/4.0/

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