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      Comparison of the Responsiveness of Cutaneous Veins of Dog and Rabbit to Adrenergic and Cholinergic Stimulation

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          Abstract

          The reactivity to sympathetic nerve activation and the metabolism of <sup>3</sup>H-norepinephrine were compared in isolated saphenous veins of dogs and rabbits. The veins of both species were equally sensitive to electrical stimulation, but the magnitude of the contractile responses to such stimulation was larger in the dog. The response to depolarization of the adrenergic nerve endings by high K<sup>+</sup> solutions was depressed by phentolamine to a greater extent in the dog than in the rabbit vein. After incubation with <sup>3</sup>H-norepinephrine, electrical stimulation caused a greater evoked release of tritiated transmitter in the dog than in the rabbit veins. These experiments suggest that the former are more densely innervated. In resting conditions and during electrical stimulation, the dog veins and the rabbit veins degraded <sup>3</sup>H norepinephrine in a different way. In both species, neuronal uptake appeared to be of minor importance in the disposition of <sup>3</sup>H-norepinephrine released during continuous electrical stimulation. The reactivity to exogenous catecholamines and acetylcholine were also compared in both veins. The apparent sensitivity to exogenous norepinephrine was greater in rabbit than in dog veins. This difference disappeared after inhibition of neuronal uptake with cocaine, suggesting that it is due to the difference in density of adrenergic innervation. There was no interspecies difference in the sensitivity of the β-adrenoceptors, but the maximal effect of β-adrenergic activation by isoproterenol was larger in the dog than in the rabbit veins. In both species acetylcholine caused inhibition of adrenergic neurotransmission, and direct activation of the venous smooth muscle cells. As regards the latter effect, dog veins were less sensitive to acetylcholine but their response was stronger than that of rabbit veins. These results suggest that the density of adrenergic innervation modulates mainly the apparent sensitivity of the venous smooth muscle to α-adrenergic activation.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1980
          1980
          19 September 2008
          : 17
          : 1
          : 27-43
          Affiliations
          Department of Medicine, Universitaire Instelling Antwerpen, Wilrijk
          Article
          158232 Blood Vessels 1980;17:27–43
          10.1159/000158232
          2f92e25e-d142-4084-9c3a-457bead2ccbb
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 21 February 1979
          : 03 July 1979
          Page count
          Pages: 17
          Categories
          Research Paper

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          β-Adrenergic,Saphenous veins,α-Adrenergic,Heterogeneity,Transmitter disposition,Neuronal uptake of norepinephrine

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