3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Chemical Mixtures Isolated from House Dust Disrupt Thyroid Receptor β Signaling

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          <p class="first" id="P1">House dust is a source of exposure to chemicals that can impact hormone regulation. This study was designed to evaluate the potential of house dust mixtures (n=137) to disrupt thyroid hormone nuclear receptor signaling in a cell-based reporter assay and examine associations with thyroid hormones (TH) measured in residents of the homes. Approximately 41% of the extracts (ranging from 10.5 −4.097 μg of dust/mL) significantly antagonized TRβ signaling by 20–67% relative to the hormone control. The concentrations of twelve flame retardants (FRs) quantified in the mixtures were significantly correlated with TRβ antagonism; however, they were inactive when tested individually. We hypothesize that the observed antagonism is due to mixture effects or unidentified compounds that co-occur with FRs. Dust extract potency was significantly associated with free thyroxine (FT4, r <sub>s</sub> = −0.64, p&lt;0.001), suggesting that more potent dust samples are associated with higher FT4 levels in residents. Overall, these results suggest that house dust is a significant source of exposure to TH-disrupting chemicals, and TRβ may have a role in mediating effects of exposure on TH levels. Additional studies are needed to identify the chemical(s) driving the observed effects on TRβ, and to determine if these changes lead to any adverse outcomes. </p>

          Related collections

          Author and article information

          Journal
          Environmental Science & Technology
          Environ. Sci. Technol.
          American Chemical Society (ACS)
          0013-936X
          1520-5851
          September 25 2018
          September 25 2018
          Affiliations
          [1 ]Nicholas School of the Environment, Duke University, Box 90328, Durham, North Carolina 27708, United States
          [2 ]Department of Surgery, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94117, United States
          Article
          10.1021/acs.est.8b03283
          6433547
          30212187
          2f961720-546b-40b7-9c49-eb684f059534
          © 2018
          History

          Comments

          Comment on this article