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      Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management

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          Abstract

          The overall increase of chronic degenerative diseases associated with ageing makes wound care a tremendous socioeconomic burden. Thus, there is a growing need to develop novel wound healing therapies to improve cutaneous wound healing. The use of regenerative therapies is becoming increasingly popular due to the low-invasive procedures needed to apply them. Platelet-rich plasma (PRP) is gaining interest due to its potential to stimulate and accelerate the wound healing process. The cytokines and growth factors forming PRP play a crucial role in the healing process. This article reviews the emerging field of skin wound regenerative therapies with particular emphasis on PRP and the role of growth factors in the wound healing process.

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          Inflammation in wound repair: molecular and cellular mechanisms.

          Sabine A. Eming, Thomas Krieg, Jeffrey Davidson (2007)
          In post-natal life the inflammatory response is an inevitable consequence of tissue injury. Experimental studies established the dogma that inflammation is essential to the establishment of cutaneous homeostasis following injury, and in recent years information about specific subsets of inflammatory cell lineages and the cytokine network orchestrating inflammation associated with tissue repair has increased. Recently, this dogma has been challenged, and reports have raised questions on the validity of the essential prerequisite of inflammation for efficient tissue repair. Indeed, in experimental models of repair, inflammation has been shown to delay healing and to result in increased scarring. Furthermore, chronic inflammation, a hallmark of the non-healing wound, predisposes tissue to cancer development. Thus, a more detailed understanding in mechanisms controlling the inflammatory response during repair and how inflammation directs the outcome of the healing process will serve as a significant milestone in the therapy of pathological tissue repair. In this paper, we review cellular and molecular mechanisms controlling inflammation in cutaneous tissue repair and provide a rationale for targeting the inflammatory phase in order to modulate the outcome of the healing response.
          Article 0 comments Cited 574 times – based on 0 reviews     Review now
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            Pathophysiology of acute wound healing.

            Jie Li, Juan Chen, Robert Kirsner (2007)
            Wound healing is a complex process that can be divided into at least 3 continuous and overlapping processes: an inflammatory reaction, a proliferative process leading to tissue restoration, and, eventually, tissue remodeling. Wound healing processes are strictly regulated by multiple growth factors and cytokines released at the wound site. Although the desirable final result of coordinated healing would be the formation of tissue with a similar structure and comparable functions as with intact skin, regeneration is uncommon (with notable exceptions such as early fetal healing); healing however results in a structurally and functionally satisfactory but not identical outcome. Alterations that disrupt controlled healing processes would extend tissue damage and repair. The pathobiologic states may lead to chronic or nonhealing wounds or excessive fibrosis.
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              Platelet-rich plasma: from basic science to clinical applications.

              Timothy E Foster, Brian L Puskas, Bert R. Mandelbaum … (2009)
              Platelet-rich plasma (PRP) has been utilized in surgery for 2 decades; there has been a recent interest in the use of PRP for the treatment of sports-related injuries. PRP contains growth factors and bioactive proteins that influence the healing of tendon, ligament, muscle, and bone. This article examines the basic science of PRP, and it describes the current clinical applications in sports medicine. This study reviews and evaluates the human studies that have been published in the orthopaedic surgery and sports medicine literature. The use of PRP in amateur and professional sports is reviewed, and the regulation of PRP by antidoping agencies is discussed.
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Funct Biomater
                Journal ID (iso-abbrev): J Funct Biomater
                Journal ID (publisher-id): jfb
                Title: Journal of Functional Biomaterials
                Publisher: MDPI
                ISSN (Electronic): 2079-4983
                Publication date (Electronic): 18 January 2018
                Publication date Collection: March 2018
                Volume: 9
                Issue: 1
                Electronic Location Identifier: 10
                Affiliations
                [1 ]Bioregenerative Medicine and Applied Surgery Research Group, Animal Medicine and Surgery Department, Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain; debora.chicharro@ 123456uchceu.es (D.C.-A.); elena.damia@ 123456uchceu.es (E.D.-G.); jcarrill@ 123456uchceu.es (J.M.C.-P.); belen.cuervo@ 123456uchceu.es (B.C.-S.); pau.pelaez@ 123456uch.ceu.es (P.P.-G.); jsopena@ 123456uchceu.es (J.J.S.-J.)
                [2 ]García Cugat Foundation for Biomedical Research, 08006 Barcelona, Spain
                Author notes
                [* ]Correspondence: mrubio@ 123456uchceu.es ; Tel.: +34-9613-69000-66015
                Author information
                https://orcid.org/0000-0002-2689-8862
                https://orcid.org/0000-0002-8104-4560
                https://orcid.org/0000-0002-3601-9745
                Article
                Publisher ID: jfb-09-00010
                DOI: 10.3390/jfb9010010
                PMC ID: 5872096
                PubMed ID: 29346333
                SO-VID: 2f96c22e-f7bc-41ad-a84c-5ecb3b506469
                Copyright © © 2018 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 29 December 2017
                Date accepted : 15 January 2018
                Categories
                Subject: Review

                Keywords: wound healing,platelet-rich plasma,growth factors,skin,stem cells
                Data availability:
                Keywords: wound healing, platelet-rich plasma, growth factors, skin, stem cells

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