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      The super super-healing MRL mouse strain.

      1
      Frontiers in biology
      Springer Nature
      MRL, regeneration, wound healing

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          Abstract

          The Murphy Roths Large (MRL/MpJ) mice provide unique insights into wound repair and regeneration. These mice and the closely related MRL/MpJ-Fas(lpr) /J and Large strains heal wounds made in multiple tissues without production of a fibrotic scar. The precise mechanism of this remarkable ability still eludes researchers, but some data has been generated and insights are being revealed. For example, MRL cells reepithelialize over dermal wound sites faster than cells of other mouse strains. This allows a blastema to develop beneath the protective layer. The MRL mice also have an altered basal immune system and an altered immune response to injury. In addition, MRL mice have differences in their tissue resident progenitor cells and certain cell cycle regulatory proteins. The difficulty often lies in separating the causative differences from the corollary differences. Remarkably, not every tissue in these mice heals scarlessly, and the specific type of wound and priming affect regeneration ability as well. The MRL/MpJ, MRL/MpJ-Fas(lpr) /J, and Large mouse strains are also being investigated for their autoimmune characteristic. Whether the two phenotypes of regeneration and autoimmunity are related remains an enigma.

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          Author and article information

          Journal
          Front Biol (Beijing)
          Frontiers in biology
          Springer Nature
          1674-7984
          1674-7984
          Dec 01 2012
          : 7
          : 6
          Affiliations
          [1 ] Department of Physiology and Biophysics, Center for Cardiovascular Research, The University of Illinois at Chicago, Chicago, IL 60612, USA.
          Article
          NIHMS469390
          10.1007/s11515-012-1192-4
          3806350
          24163690
          2f9b0d07-ce78-4188-9591-40fd0e8c4926
          History

          MRL,regeneration,wound healing
          MRL, regeneration, wound healing

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