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      Investigation of Atrial Vortices Using a Novel Right Heart Model and Possible Implications for Atrial Thrombus Formation

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          Abstract

          The main aim of this paper is to characterize vortical flow structures in the healthy human right atrium, their impact on wall shear stresses and possible implications for atrial thrombus formation. 3D Particle Tracking Velocimetry is applied to a novel anatomically accurate compliant silicone right heart model to study the phase averaged and fluctuating flow velocity within the right atrium, inferior vena cava and superior vena cava under physiological conditions. We identify the development of two vortex rings in the bulk of the right atrium during the atrial filling phase leading to a rinsing effect at the atrial wall which break down during ventricular filling. We show that the vortex ring formation affects the hemodynamics of the atrial flow by a strong correlation ( ρ = 0.7) between the vortical structures and local wall shear stresses. Low wall shear stress regions are associated with absence of the coherent vortical structures which might be potential risk regions for atrial thrombus formation. We discuss possible implications for atrial thrombus formation in different regions of the right atrium.

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          Most cited references 32

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          Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography.

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            Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure.

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              BLOOD FLOW IN ARTERIES

               David Ku (1997)
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                Author and article information

                Contributors
                guelan@ifu.baug.ethz.ch
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                1 December 2017
                1 December 2017
                2017
                : 7
                Affiliations
                [1 ]ISNI 0000 0001 2156 2780, GRID grid.5801.c, ETH Zurich, Institute of Environmental Engineering, ; Zurich, 8093 Switzerland
                [2 ]ISNI 0000 0004 0478 9977, GRID grid.412004.3, University Heart Center, Department of Cardiology, ; Zurich, 8091 Switzerland
                [3 ]ISNI 0000 0004 1937 0650, GRID grid.7400.3, Center for Integrative Human Physiology, University of Zurich, ; Zurich, 8091 Switzerland
                [4 ]GRID grid.482286.2, Institute for Biomedical Engineering, University and ETH Zurich, ; Zurich, 8092 Switzerland
                Article
                17117
                10.1038/s41598-017-17117-3
                5711865
                29196688
                © The Author(s) 2017

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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