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      Follicle-Stimulating Hormone versus Human Menopausal Gonadotropin for in vitro Fertilization: Results of a Meta-Analysis

      Hormone Research in Paediatrics

      S. Karger AG

      Infertility, In vitro fertilization, Gonadotropins, Meta-analysis, FSH vs. hMG in IVF

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          The observation of adverse effects of high-follicular-phase LH levels on fertilization, cleavage, embryo quality and pregnancy suggests that exogenous LH administration for ovarian stimulation in IVF may also be detrimental. The purpose of this study was to compare the use of FSH with hMG in IVF by conducting a systematic overview and meta-analysis of the evidence in the literature from randomized trials comparing the two gonadotropins. The data were extracted and pooled from eight studies that satisfied the inclusion criteria. The results show that FSH performs significantly better than hMG and is associated with at least 50% higher clinical pregnancy rates.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          05 December 2008
          : 43
          : 5
          : 224-229
          Departments of Obstetrics and Gynecology and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont., Canada
          184283 Horm Res 1995;43:224–229
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Proceedings of the Ares Serono Satellite Symposium


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