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      Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy.

      1 , ,
      Neurology
      Ovid Technologies (Wolters Kluwer Health)

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          Abstract

          Fatigue is commonly reported in many neurologic illnesses, including multiple sclerosis, Parkinson disease, myasthenia gravis, traumatic brain injury, and stroke. Fatigue contributes substantially to decrements in quality of life and disability in these illnesses. Despite the clear impact of fatigue as a disabling symptom, our understanding of fatigue pathophysiology is limited and current treatment options rarely lead to meaningful improvements in fatigue. Progress continues to be hampered by issues related to terminology and assessment. In this article, we propose a unified taxonomy and a novel assessment approach to addressing distinct aspects of fatigue and fatigability in clinical and research settings. This taxonomy is based on our current knowledge of the pathophysiology and phenomenology of fatigue and fatigability. Application of our approach indicates that the assessment and reporting of fatigue can be clarified and improved by utilizing this taxonomy and creating measures to address distinct aspects of fatigue and fatigability. We review the strengths and weaknesses of several common measures of fatigue and suggest, based on our model, that many research questions may be better addressed by using multiple measures. We also provide examples of how to apply and validate the taxonomy and suggest directions for future research.

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          Author and article information

          Journal
          Neurology
          Neurology
          Ovid Technologies (Wolters Kluwer Health)
          1526-632X
          0028-3878
          Jan 22 2013
          : 80
          : 4
          Affiliations
          [1 ] Department of Neurology, University of Colorado Denver, Aurora, USA. benzi.kluger@ucdenver.edu
          Article
          80/4/409
          10.1212/WNL.0b013e31827f07be
          3589241
          23339207
          2fd6165f-2fe5-454c-8240-fcf870422f03
          History

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