Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure.

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Abstract

Chloride plays a role in renal salt sensing, neurohormonal activation, and regulation of diuretic targets, and hypochloremia predicts mortality in acute heart failure (AHF). AHF therapies, such as diuretics, alter chloride homeostasis. We studied the association between (changes in) chloride levels and diuretic responsiveness, decongestion, and mortality in patients with AHF.

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Author and article information

Journal

Journal ID (iso-abbrev): Circ Heart Fail

Title: Circulation. Heart failure

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1941-3297

ISSN (Print): 1941-3289

Publication date (Electronic): Aug 2016

Volume: 9

Issue: 8

Affiliations

[1 ] From the University Medical Center, University of Groningen, The Netherlands (J.M.t.M., K.D., H.L.H., D.J.v.V., A.A.V.); Program of Applied Translational Research, Yale University School of Medicine, New Haven, CT (J.M.t.M., J.S.H., J.M.T.); Brigham and Women's Hospital, Boston, MA (M.M.G.); University of Brescia, Italy (M.M.); Inova Heart and Vascular Institute, Falls Church, VA (C.M.O.); University of California at San Francisco and San Francisco Veterans Affairs Medical Center (J.R.T.); Medical University, Clinical Military Hospital, Wroclaw, Poland (P.P.); Momentum Research, Durham, NC (G.C., B.D.); University of Hull, Kingston upon Hull, United Kingdom (J.G.C.); Merck Research Laboratories, Rahway, NJ (D.M.B.); Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (J.M.T.).

[2 ] From the University Medical Center, University of Groningen, The Netherlands (J.M.t.M., K.D., H.L.H., D.J.v.V., A.A.V.); Program of Applied Translational Research, Yale University School of Medicine, New Haven, CT (J.M.t.M., J.S.H., J.M.T.); Brigham and Women's Hospital, Boston, MA (M.M.G.); University of Brescia, Italy (M.M.); Inova Heart and Vascular Institute, Falls Church, VA (C.M.O.); University of California at San Francisco and San Francisco Veterans Affairs Medical Center (J.R.T.); Medical University, Clinical Military Hospital, Wroclaw, Poland (P.P.); Momentum Research, Durham, NC (G.C., B.D.); University of Hull, Kingston upon Hull, United Kingdom (J.G.C.); Merck Research Laboratories, Rahway, NJ (D.M.B.); Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (J.M.T.). a.a.voors@umcg.nl.

Article

Publisher Item ID: CIRCHEARTFAILURE.116.003109

DOI: 10.1161/CIRCHEARTFAILURE.116.003109

PubMed ID: 27507112

SO-VID: 2fdfc2f6-64b8-416d-8078-8441a1fe1d06

History

Keywords: chlorides,blood urea nitrogen,creatinine,diuretics,electrolytes

Data availability:

Keywords: chlorides, blood urea nitrogen, creatinine, diuretics, electrolytes

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