+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Comparison between Low- and Standard-Dose ACTH Tests in Premature Infants at Risk for Chronic Lung Disease

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          In order to find a sensitive method to evaluate adrenocortical function in premature infants, we compared low- (0.5 μg/1.73 m<sup>2</sup>) and standard-dose (250 μg/1.73 m<sup>2</sup>) adrenocorticotropin tests (LD- and SD-ACTH) in 12 very-low-birth-weight infants before and 2 days after the end of dexamethasone therapy (duration 9–14 days) for chronic lung disease. Basal serum cortisol levels were inappropriately low in several infants already before dexamethasone therapy (median 190, range 60–357 nmol/l). The 95% confidence intervals of mean serum cortisol levels at 20 min were equal in LD- and SD-ACTH, while at 60 min, the low-dose gave a clearly lower response than the standard-dose test. The LD-ACTH can be used in premature infants as in older children and adults, but the criteria for adrenocortical insufficiency need to be defined.

          Related collections

          Most cited references 5

          • Record: found
          • Abstract: not found
          • Article: not found

          The role of the low dose (1 microgram) adrenocorticotropin test in the evaluation of patients with pituitary diseases

           K Tordjman (1995)
            • Record: found
            • Abstract: not found
            • Article: not found

            Clinical review 62: Laboratory assessment of adrenal insufficiency

             S Grinspoon (1994)
              • Record: found
              • Abstract: not found
              • Article: not found

              The Low Dose (1- g) Adrenocorticotropin Stimulation Test in the Evaluation of Patients with Suspected Central Adrenal Insufficiency

               L. M. Thaler (1998)

                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                July 2000
                13 July 2000
                : 52
                : 6
                : 274-278
                Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
                23494 Horm Res 1999;52:274–278
                © 2000 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 1, Tables: 2, References: 27, Pages: 5
                Original Paper


                Comment on this article