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      Hypoxia and Renal Tubulointerstitial Fibrosis.

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          Abstract

          Hypoxia, one of the most common causes of kidney injury, is a key pathological condition in various kidney diseases. Renal fibrosis is the terminal pathway involved in the continuous progression of chronic kidney disease (CKD), characterized by glomerulosclerosis and tubulointerstitial fibrosis (TIF). Recent studies have shown that hypoxia is a key factor promoting the progression of TIF. Loss of microvasculature, reduced oxygen dispersion, and metabolic abnormality of cells in the kidney are the main causes of the hypoxic state. Hypoxia can, in turn, profoundly affect the tubular epithelial cells, endothelial cells, pericytes, fibroblasts, inflammatory cells, and progenitor cells. In this chapter, we reviewed the critical roles of hypoxia in the pathophysiology of TIF and discussed the potential of anti-hypoxia as its promising therapeutic target.

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          Author and article information

          Journal
          Adv Exp Med Biol
          Advances in experimental medicine and biology
          Springer Science and Business Media LLC
          0065-2598
          0065-2598
          2019
          : 1165
          Affiliations
          [1 ] Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
          [2 ] Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China. liubc64@163.com.
          Article
          10.1007/978-981-13-8871-2_23
          31399980
          30029e1d-bb69-4da5-bf32-97ec9c68587e
          History

          Hypoxia,Hypoxia-inducible factor,Tubulointerstitial fibrosis

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