3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Autophagy is required for performance adaptive response to resistance training and exercise-induced adult neurogenesis.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Endurance training promotes exercise-induced adaptations in brain, like hippocampal adult neurogenesis and autophagy induction. However, resistance training effect on the autophagy response in the brain has not been much explored. Questions such as whether partial systemic autophagy or the length of training intervention affect this response deserve further attention. Therefore, 8-week-old male wild-type (Wt; n = 36) and systemic autophagy-deficient (atg4b-/- , KO; n = 36) mice were randomly distributed in three training groups, resistance (R), endurance (E), and control (non-trained), and in two training periods, 2 or 14 weeks. R and E maximal tests were evaluated before and after the training period. Forty-eight hours after the end of training program, cerebral cortex, striatum, hippocampus, and cerebellum were extracted for the analysis of autophagy proteins (LC3B-I, LC3B-II, and p62). Additionally, hippocampal adult neurogenesis was determined by doublecortin-positive cells count (DCX+) in brain sections. Our results show that, in contrast to Wt, KO were unable to improve R after both trainings. Autophagy levels in brain areas may be modified by E training only in cerebral cortex of Wt trained for 14 weeks, and in KO trained for 2 weeks. DCX + in Wt increased in R and E after both periods of training, with R for 14 weeks more effective than E. Interestingly, no changes in DCX + were observed in KO after 2 weeks, being even undetectable after 14 weeks of intervention. Thus, autophagy is crucial for R performance and for exercise-induced adult neurogenesis.

          Related collections

          Author and article information

          Journal
          Scand J Med Sci Sports
          Scandinavian journal of medicine & science in sports
          Wiley
          1600-0838
          0905-7188
          Feb 2020
          : 30
          : 2
          Affiliations
          [1 ] Departamento de Biología Funcional, Área de Fisiología, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Oviedo, Spain.
          [2 ] Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.
          [3 ] Departamento de Morfología y Biología Celular, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Oviedo, Spain.
          [4 ] Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain.
          Article
          10.1111/sms.13586
          31650583
          3004961e-fbdd-4d97-83b7-2a4e5348918f
          © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
          History

          Atg4b,autophagy impairment,brain,endurance training,physical activity

          Comments

          Comment on this article