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      Zinc finger protein ZBTB20 promotes cell proliferation in non-small cell lung cancer through repression of FoxO1.

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          Abstract

          In the present study, we found that ZBTB20, a member of the POK (POZ and Krüppel) family of transcriptional repressors, was significantly up-regulated in lung cancer tissues, compared with adjacent normal tissues. Our in vitro studies further found that ZBTB20 overexpression promoted, while its inhibition using small interfering RNA suppressed cell proliferation. Consistently, key regulators in cell-cycle progression, such as Cyclin D1, Cyclin E, P21 and P27, were also regulated by ZBTB20. At the molecular level, we further revealed that FoxO1, a tumor suppressor in multiple human cancers, was transcriptionally repressed by ZBTB20. Therefore, our results highlight an important role for ZBTB20 in controlling NSCLC development, which might be helpful to identify potential therapeutic targets for its treatment.

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          Author and article information

          Journal
          FEBS Lett.
          FEBS letters
          1873-3468
          0014-5793
          Dec 20 2014
          : 588
          : 24
          Affiliations
          [1 ] Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. Electronic address: Zjungang_12@163.com.
          [2 ] Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
          Article
          S0014-5793(14)00739-X
          10.1016/j.febslet.2014.10.005
          25311537
          302890b7-0782-4e51-92f5-7a9e8cffb6e4
          Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
          History

          Cell cycle,FoxO1,Non-small cell lung cancer,Zinc finger and BTB domain-containing 20

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