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      Safety of MF59™ adjuvant

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      Vaccine

      Elsevier BV

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          Abstract

          The need to enhance the immunogenicity of purified subunit antigens has prompted the development of new adjuvants. The adjuvant emulsion MF59 has been tested in animals in combination with different antigens and finally evaluated in humans. It was licensed after the successful outcome of preclinical and clinical testing. This paper summarizes the main characteristics of the MF59 adjuvant, including animal testing, clinical experience with various vaccines, and information from current postmarketing surveillance data. This review supports the hypothesis that MF59 is a safe adjuvant for human use.

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          Author and article information

          Journal
          Vaccine
          Vaccine
          Elsevier BV
          0264410X
          June 2008
          June 2008
          : 26
          : 26
          : 3209-3222
          Article
          10.1016/j.vaccine.2008.03.093
          18462843
          303ae65a-1d5c-4844-b038-01e39415adb9
          © 2008

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