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      Glycosaminoglycans in Embryonic and Postnatal Human Cornea


      Ophthalmic Research

      S. Karger AG

      Human cornea, Development, Aging, Hexosamine, Keratan sulphate, Chondroitin sulphate

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          Human corneas were analyzed for glycosaminoglycans during various stages of embryonic development and at different postnatal ages. The development and aging of the cornea was accompanied by a transient increase of glycosaminoglycan hexosamine up to 2 years of age and thereafter by a stepwise decrease to a value which seemed to be constant in all age groups. Keratan sulphate formed a minor part of glycosaminoglycans in fetal, premature and newborn corneas but it predominated in older corneas. The development of the cornea was characterized by a decrease in sulphation of chondroitin sulphate. No hyaluronate was found in the fetal corneas available for this study.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 7
          : 6
          : 452-458
          Eye Research Laboratory, Czechoslovak Academy of Sciences, Prague
          264786 Ophthalmic Res 1975;7:452–458
          © 1975 S. Karger AG, Basel

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          Page count
          Pages: 7


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