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      Glycosaminoglycans in Embryonic and Postnatal Human Cornea

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      Ophthalmic Research

      S. Karger AG

      Human cornea, Development, Aging, Hexosamine, Keratan sulphate, Chondroitin sulphate

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          Abstract

          Human corneas were analyzed for glycosaminoglycans during various stages of embryonic development and at different postnatal ages. The development and aging of the cornea was accompanied by a transient increase of glycosaminoglycan hexosamine up to 2 years of age and thereafter by a stepwise decrease to a value which seemed to be constant in all age groups. Keratan sulphate formed a minor part of glycosaminoglycans in fetal, premature and newborn corneas but it predominated in older corneas. The development of the cornea was characterized by a decrease in sulphation of chondroitin sulphate. No hyaluronate was found in the fetal corneas available for this study.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1975
          1975
          03 December 2009
          : 7
          : 6
          : 452-458
          Affiliations
          Eye Research Laboratory, Czechoslovak Academy of Sciences, Prague
          Article
          264786 Ophthalmic Res 1975;7:452–458
          10.1159/000264786
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
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