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      Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: A pilot study

      , , , , ,

      Neurology

      Ovid Technologies (Wolters Kluwer Health)

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          Abstract

          The lateral segment of the globus pallidus (GPl) is thought to be overactive in levodopa-induced dyskinesia in PD. Stimulation of cannabinoid receptors in the GPl reduces gamma-aminobutyric acid (GABA) reuptake and enhances GABA transmission and may thus alleviate dyskinesia. In a randomized, double-blind, placebo-controlled, crossover trial (n = 7), the authors demonstrate that the cannabinoid receptor agonist nabilone significantly reduces levodopa-induced dyskinesia in PD.

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          Author and article information

          Journal
          Neurology
          Neurology
          Ovid Technologies (Wolters Kluwer Health)
          0028-3878
          1526-632X
          December 11 2001
          December 11 2001
          : 57
          : 11
          : 2108-2111
          Article
          10.1212/WNL.57.11.2108
          11739835
          © 2001

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