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The lateral segment of the globus pallidus (GPl) is thought to be overactive in levodopa-induced
dyskinesia in PD. Stimulation of cannabinoid receptors in the GPl reduces gamma-aminobutyric
acid (GABA) reuptake and enhances GABA transmission and may thus alleviate dyskinesia.
In a randomized, double-blind, placebo-controlled, crossover trial (n = 7), the authors
demonstrate that the cannabinoid receptor agonist nabilone significantly reduces levodopa-induced
dyskinesia in PD.