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      Interaction between Somatostatin and TRH on Growth Hormone Secretion in Perifused Human Growth Hormone Tumor Cells

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          Abstract

          The interaction between somatostatin (SRIF) and thyrotropin-releasing hormone (TRH) on growth hormone (GH) release has been studied on dispersed somatotrophic tumor cells obtained from 7 acromegalic patients. TRH increased GH secretion in 4 cases and SRIF decreased GH secretion in 5 cases. When TRH and SRIF were concomitantly perifused, SRIF, when active by itself, prevented and reversed the TRH-induced stimulation of GH release, while TRH never antagonized the inhibitory effect of SRIF. We conclude that, in these adenomatous cells, the physiological inhibitory factor (SRIF) overcomes the nonphysiological stimulatory factor (TRH) in the control of GH secretion.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1985
          1985
          26 November 2008
          : 21
          : 4
          : 235-239
          Affiliations
          aInserm U-223 and CNRS 484, Faculté de Médecine Pitié-Salpêtrière, Paris; bService d’Endocrinologie, Hôpital la Pitié, Paris; cFondation de Recherche en Hormonologie, Fresnes, France
          Article
          180055 Horm Res 1985;21:235–239
          10.1159/000180055
          2861154
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 5
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