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An RF-powered wireless multi-channel implantable bio-sensing microsystem.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Prostheses and Implants, Mice, Equipment Design, methods, instrumentation, Electrocardiography, Blood Pressure Determination, Biosensing Techniques, Animals

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      An RF-powered wireless three-channel implantable bio-sensing microsystem is developed with blood pressure, EKG, and core body temperature sensing capability for untethered genetically engineered laboratory mice real-time monitoring. A flat silicone blood pressure sensing cuff with a MEMS capacitive pressure sensor is employed to form a novel less-invasive blood pressure sensor, which avoids vessel occlusion, bleeding, and blood clotting associated with the conventional catheter-based sensors. The implantable microsystem can be powered by an adaptively controlled external RF energy source at 4 MHz to ensure a stable on-chip power supply. The overall system dissipates 200 microW and achieves a blood pressure sensing resolution of 1 mmHg within 1 kHz bandwidth, an EKG sensing resolution of 7.4 bits, and a temperature sensitivity of 19 mV/°C measured from 22 °C to 43 °C. A prototype packaged sensor exhibits a weight of 495 mg, which is approximately 2% of a laboratory mouse body mass. On-going research effort is devoted to demonstrate in vivo performance in laboratory animals.

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