- Record: found
- Abstract: found
- Article: not found
Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
review-article
4 November 2003
Antiviral therapy,
Anticancer therapy,
Chemotherapy,
Nucleoside analogue,
Deoxyribonucleoside kinase,
Ribonucleoside kinase,
ADK, adenosine kinase,
AIDS, aquired immunodeficiency syndrome,
AraC, 1-β-d-arabinofuranosylcytosine (Cytarabine),
AraG, 9-β-d-arabinofuranosylguanine (Nelarabine),
AZT, 3′-azido-2′,3′-dideoxythymidine (Zidovudine),
CAFdA, 2-chloro-2′-fluoro-9-β-d-arabinofuranosyladenine (Clofarabine),
CdA, 2-chloro-2′-deoxyadenosine (Cladribine),
dCK, deoxycytidine kinase,
ddC, 2′,3′-dideoxycytidine (Zalcitabine),
ddI, 2′,3′-dideoxyinosine (Didanosine),
dGK, deoxyguanosine kinase,
dFdC, 2′,2′-difluorodeoxycytidine (Gemcitabine),
dNK, deoxyribonucleoside kinase,
d4T, 2′,3′-didehydro-3′-deoxythymidine (Stavudine),
F-AraA, 2-fluoro-9-β-d-arabinofuranosyladenine (Fludarabine),
FDA, Food and Drug Administration,
FIAU, 1-(2′-deoxy-2′-fluoro-β-d-arabinofuranosyl)-5-iodouracil (Fialuridine),
HBV, hepatitis B virus,
mtDNA, mitochondrial DNA,
HIV, human immunodeficiency virus,
NA, nucleoside analogue,
NDPK, nucleoside diphosphate kinase,
NMPK, nucleoside monophosphate kinase,
5′-NT, 5′-nucleotidase,
rNK, ribonucleoside kinase,
RR, ribonucleotide reductase,
RT, reverse transcriptase,
TK1, thymidine kinase 1,
TK2, thymidine kinase 2,
UCK1, uridine-cytidine kinase 1,
UCK2, uridine-cytidine kinase 2,
3TC, 2′-deoxy-3′-thiacytidine (Lamivudine)
Read this article at
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Structural analogues of nucleosides, nucleoside analogues (NA), are used in the treatment of cancer and viral infections. Antiviral NAs inhibit replication of the viral genome, whereas anticancer NAs inhibit cellular DNA replication and repair. NAs are inactive prodrugs that are dependent on intracellular phosphorylation to their pharmacologically active triphosphate form. The deoxyribonucleoside kinases (dNK) and ribonucleoside kinases (rNK) catalyze the first phosphorylation step, converting deoxyribonucleosides and ribonucleosides to their corresponding monophosphate form. The dNKs have been studied intensively, whereas the rNKs have not been as thoroughly investigated. This overview is focused on the substrate specificity, tissue distribution, and subcellular location of the mammalian dNKs and rNKs and their role in the activation of NAs.
Related collections
Most cited references214
- Record: found
- Abstract: found
- Article: not found
The mitochondrial genome: structure, transcription, translation and replication.
J Taanman (1999)
- Record: found
- Abstract: found
- Article: not found
Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia.
Celia Schiffer, Frederick Appelbaum, Charles Larson … (2000)
Author and article information
antiviral therapy,anticancer therapy,chemotherapy,nucleoside analogue,deoxyribonucleoside kinase,ribonucleoside kinase,adk, adenosine kinase,aids, aquired immunodeficiency syndrome,arac, 1-β-d-arabinofuranosylcytosine (cytarabine),arag, 9-β-d-arabinofuranosylguanine (nelarabine),azt, 3′-azido-2′,3′-dideoxythymidine (zidovudine),cafda, 2-chloro-2′-fluoro-9-β-d-arabinofuranosyladenine (clofarabine),cda, 2-chloro-2′-deoxyadenosine (cladribine),dck, deoxycytidine kinase,ddc, 2′,3′-dideoxycytidine (zalcitabine),ddi, 2′,3′-dideoxyinosine (didanosine),dgk, deoxyguanosine kinase,dfdc, 2′,2′-difluorodeoxycytidine (gemcitabine),dnk, deoxyribonucleoside kinase,d4t, 2′,3′-didehydro-3′-deoxythymidine (stavudine),f-araa, 2-fluoro-9-β-d-arabinofuranosyladenine (fludarabine),fda, food and drug administration,fiau, 1-(2′-deoxy-2′-fluoro-β-d-arabinofuranosyl)-5-iodouracil (fialuridine),hbv, hepatitis b virus,mtdna, mitochondrial dna,hiv, human immunodeficiency virus,na, nucleoside analogue,ndpk, nucleoside diphosphate kinase,nmpk, nucleoside monophosphate kinase,5′-nt, 5′-nucleotidase,rnk, ribonucleoside kinase,rr, ribonucleotide reductase,rt, reverse transcriptase,tk1, thymidine kinase 1,tk2, thymidine kinase 2,uck1, uridine-cytidine kinase 1,uck2, uridine-cytidine kinase 2,3tc, 2′-deoxy-3′-thiacytidine (lamivudine)
antiviral therapy, anticancer therapy, chemotherapy, nucleoside analogue, deoxyribonucleoside kinase, ribonucleoside kinase, adk, adenosine kinase, aids, aquired immunodeficiency syndrome, arac, 1-β-d-arabinofuranosylcytosine (cytarabine), arag, 9-β-d-arabinofuranosylguanine (nelarabine), azt, 3′-azido-2′,3′-dideoxythymidine (zidovudine), cafda, 2-chloro-2′-fluoro-9-β-d-arabinofuranosyladenine (clofarabine), cda, 2-chloro-2′-deoxyadenosine (cladribine), dck, deoxycytidine kinase, ddc, 2′,3′-dideoxycytidine (zalcitabine), ddi, 2′,3′-dideoxyinosine (didanosine), dgk, deoxyguanosine kinase, dfdc, 2′,2′-difluorodeoxycytidine (gemcitabine), dnk, deoxyribonucleoside kinase, d4t, 2′,3′-didehydro-3′-deoxythymidine (stavudine), f-araa, 2-fluoro-9-β-d-arabinofuranosyladenine (fludarabine), fda, food and drug administration, fiau, 1-(2′-deoxy-2′-fluoro-β-d-arabinofuranosyl)-5-iodouracil (fialuridine), hbv, hepatitis b virus, mtdna, mitochondrial dna, hiv, human immunodeficiency virus, na, nucleoside analogue, ndpk, nucleoside diphosphate kinase, nmpk, nucleoside monophosphate kinase, 5′-nt, 5′-nucleotidase, rnk, ribonucleoside kinase, rr, ribonucleotide reductase, rt, reverse transcriptase, tk1, thymidine kinase 1, tk2, thymidine kinase 2, uck1, uridine-cytidine kinase 1, uck2, uridine-cytidine kinase 2, 3tc, 2′-deoxy-3′-thiacytidine (lamivudine)